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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal lacrimal gland development
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Accession:MP:0013331 term browser browse the term
Definition:aberrant formation or incomplete differentiation of the paired almond-shaped glands, one for each eye, that secrete the aqueous layer of the tear film; each lacrimal gland develops through branching morphogenesis regulated by FGF signaling; at E12.5, the conjunctival epithelium at the temporal side of the mouse eyes invades the Fgf10-expressing mesenchyme to form the initial lacrimal gland bud; the bud elongates posteriorly until E15.5 when secondary branching begins to establish the complex tubuloalveolar structure; this eventually gives rise to the mature lacrimal gland composed of numerous ducts, acini and connective tissue



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Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal gland development 7
          abnormal lacrimal gland development 0
            abnormal lacrimal gland branching morphogenesis 0
            abnormal lacrimal gland bud elongation 0
            abnormal lacrimal gland bud morphology + 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    vision/eye phenotype 98
      abnormal eye morphology 86
        abnormal ocular surface morphology 2
          abnormal lacrimal apparatus morphology 2
            abnormal lacrimal gland morphology 2
              abnormal lacrimal gland development 0
                abnormal lacrimal gland branching morphogenesis 0
                abnormal lacrimal gland bud elongation 0
                abnormal lacrimal gland bud morphology + 0
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