Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal optic fissure closure
go back to main search page
Accession:MP:0012535 term browser browse the term
Definition:failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas
Synonyms:exact_synonym: abnormal choroid fissure closure;   abnormal choroidal fissure closure;   abnormal embryonic fissure closure;   abnormal fetal fissure closure;   abnormal foetal fissure closure;   abnormal retinal fissure closure;   optic fissure closure defects;   persistent optic fissure

show annotations for term's descendants           Sort by:

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5400
    vision/eye phenotype 98
      abnormal eye morphology 86
        abnormal eye development 7
          abnormal optic fissure closure 0
            delayed optic fissure closure 0
paths to the root