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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal kidney interstitium morphology
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Accession:MP:0011425 term browser browse the term
Definition:any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure
Synonyms:exact_synonym: abnormal renal interstitium morphology;   kidney interstitium dysplasia;   renal interstitium dysplasia



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renal interstitial fibrosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednra endothelin receptor type A IMP RGD PMID:12538737 RGD:1581844 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B IMP RGD PMID:12538737 RGD:1581844 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Lepr leptin receptor disease_progression IMP
IAGP
compared to SS/JrHsdMcwi
DNA:mutations:cds: : (rat)
RGD PMID:27465994 PMID:30278832 PMID:10901178 RGD:12911217, RGD:401960095, RGD:401965414 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Leprem2Mcwi leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin disease_progression IMP compared to SS/JrHsdMcwi RGD PMID:27465994 RGD:12911217
G Mmp2 matrix metallopeptidase 2 ameliorates IMP compared to wild type SS RGD PMID:37643020 RGD:401827835 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp2em2Mcwi matrix metallopeptidase 2; zinc finger nuclease induced mutant 2, Medical College of Wisconsin ameliorates IMP compared to wild type SS RGD PMID:37643020 RGD:401827835
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 IMP compared to FHH RGD PMID:24722447 RGD:12910103 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr4a1m1Mcwi nuclear receptor subfamily 4, group A, member 1; mutation 1, Medical College of Wisconsin IMP compared to FHH RGD PMID:24722447 RGD:12910103
G Sod3 superoxide dismutase 3 onset IMP compared to SS/JrHsdMcwi RGD PMID:31972339 RGD:150573712 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Sod3m1Mcwi superoxide dismutase 3; mutation 1, Medical College of Wisconsin onset IMP compared to SS/JrHsdMcwi RGD PMID:31972339 RGD:150573712

Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5402
    renal/urinary system phenotype 649
      abnormal renal/urinary system morphology 279
        abnormal kidney morphology 272
          abnormal kidney interstitium morphology 22
            abnormal perihilar interstitium morphology 0
            renal interstitial fibrosis 22
paths to the root