Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased T follicular helper cell number
go back to main search page
Accession:MP:0010187 term browser browse the term
Definition:reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production
Synonyms:xref: CL:0002038


show annotations for term's descendants           Sort by:
decreased T follicular helper cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper transcription factor, ATF-like IAGP MGI PMID:20421391 NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861 		JBrowse link
G Bcl6 B cell leukemia/lymphoma 6 IAGP MGI PMID:21636294 PMID:23027924 PMID:23455674 PMID:23980208 NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602 		JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 IAGP MGI PMID:23997217 NCBI chr 6:128,386,407...128,401,873
Ensembl chr 6:128,386,407...128,401,894 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IAGP MGI PMID:20826752 NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028 		JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 IAGP MGI PMID:20826752 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069 		JBrowse link
G Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 IAGP MGI PMID:24140642 NCBI chr 4:63,642,837...63,663,296
Ensembl chr 4:63,642,840...63,663,350 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16242
    immune system phenotype 5382
      abnormal immune system morphology 3803
        abnormal immune system cell morphology 2667
          abnormal leukocyte morphology 2646
            abnormal leukocyte cell number 2368
              decreased leukocyte cell number 1566
                decreased lymphocyte cell number 1228
                  decreased T cell number 756
                    decreased T-helper cell number 43
                      decreased T follicular helper cell number 6
Path 2
Term Annotations click to browse term
  mammalian phenotype 16242
    immune system phenotype 5382
      abnormal immune system morphology 3803
        abnormal immune system cell morphology 2667
          abnormal leukocyte morphology 2646
            abnormal mononuclear cell morphology 2161
              abnormal lymphocyte morphology 1750
                abnormal T cell morphology 1126
                  abnormal effector T cell morphology 818
                    abnormal CD4-positive, alpha beta T cell morphology 590
                      abnormal CD4-positive helper T cell morphology 144
                        abnormal T follicular helper cell morphology 23
                          abnormal T follicular helper cell number 23
                            decreased T follicular helper cell number 6
paths to the root