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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal mammary gland epithelium physiology
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Accession:MP:0010172 term browser browse the term
Definition:any functional anomaly of the mammary gland epithelium which is normally enveloped by a basement membrane, embedded into fatty connective tissue stroma, and organized as a bilayer, with an inner luminal layer of secretory epithelial cells, and an outer basal layer; each cell layer expresses specific molecular markers; luminal epithelial cells are characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin, whereas basal cells (aka myoepithelial cells) express smooth muscle contractile proteins; in functionally differentiated mammary gland, during lactation, luminal cells produce milk, whereas myoepithelial cells are contractile and serve for milk expulsion



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increased mammary gland epithelial cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B IMP RGD PMID:30893315 RGD:126908018 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn1bem1Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc IMP RGD PMID:30893315 RGD:126908018
G Cdkn1bem4Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc IMP RGD PMID:30893315 RGD:126908018

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5415
    integument phenotype 171
      abnormal skin adnexa physiology 5
        abnormal mammary gland physiology 5
          abnormal mammary gland epithelium physiology 5
            abnormal mammary gland myoepithelium physiology + 0
            decreased mammary gland epithelial cell proliferation 0
            increased mammary gland epithelial cell proliferation 5
Path 2
Term Annotations click to browse term
  mammalian phenotype 5415
    endocrine/exocrine gland phenotype 394
      abnormal gland physiology 85
        abnormal exocrine gland physiology 9
          abnormal apocrine gland physiology 5
            abnormal mammary gland physiology 5
              abnormal mammary gland epithelium physiology 5
                abnormal mammary gland myoepithelium physiology + 0
                decreased mammary gland epithelial cell proliferation 0
                increased mammary gland epithelial cell proliferation 5
paths to the root