Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
go back to main search page
Accession:MP:0010169 term browser browse the term
Definition:a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release
Synonyms:exact_synonym: decreased CD4-positive, CD25-positive, alpha-beta Treg number;   decreased CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte number;   reduced CD4-positive, CD25-positive, alpha-beta Treg number;   reduced CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number;   reduced CD4-positive, CD25-positive, alpha-beta regulatory T-cell number
 broad_synonym: decreased suppressor T cell number;   decreased suppressor T lymphocyte number;   reduced suppressor T cell number;   reduced suppressor T-lymphocyte number
 xref: CL:0000792


show annotations for term's descendants           Sort by:
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S BBDP.ACI-(D2Arb16-D2Rat63)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:190,602,746...222,436,696 JBrowse link
S BBDP.ACI-(D2Mit8-D2Rat354)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:143,657,411...191,987,650 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5374
    immune system phenotype 492
      abnormal immune system morphology 187
        abnormal immune system cell morphology 147
          abnormal leukocyte morphology 147
            abnormal leukocyte cell number 134
              abnormal lymphocyte cell number 92
                abnormal T cell number 62
                  abnormal regulatory T cell number 7
                    decreased regulatory T cell number 3
                      decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 2
                        decreased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0
                        decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5374
    immune system phenotype 492
      abnormal immune system morphology 187
        abnormal immune system cell morphology 147
          abnormal leukocyte morphology 147
            abnormal mononuclear cell morphology 120
              abnormal lymphocyte morphology 98
                abnormal T cell morphology 68
                  abnormal effector T cell morphology 23
                    abnormal CD4-positive, alpha beta T cell morphology 17
                      abnormal CD4-positive, alpha-beta T cell number 13
                        decreased CD4-positive, alpha-beta T cell number 8
                          decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 2
                            decreased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0
                            decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0
paths to the root