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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
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Accession:MP:0010169 term browser browse the term
Definition:a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release
Synonyms:exact_synonym: decreased CD4-positive, CD25-positive, alpha-beta Treg number;   decreased CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte number;   reduced CD4-positive, CD25-positive, alpha-beta Treg number;   reduced CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number;   reduced CD4-positive, CD25-positive, alpha-beta regulatory T-cell number
 broad_synonym: decreased suppressor T cell number;   decreased suppressor T lymphocyte number;   reduced suppressor T cell number;   reduced suppressor T-lymphocyte number
 xref: CL:0000792



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decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S BBDP.ACI-(D2Arb16-D2Rat63)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:190,602,746...222,436,696 JBrowse link
S BBDP.ACI-(D2Mit8-D2Rat354)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:143,657,411...191,987,650 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system cell morphology 154
          abnormal leukocyte morphology 154
            abnormal leukocyte cell number 138
              abnormal lymphocyte cell number 93
                abnormal T cell number 63
                  abnormal regulatory T cell number 7
                    decreased regulatory T cell number 3
                      decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 2
                        decreased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0
                        decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system cell morphology 154
          abnormal leukocyte morphology 154
            abnormal mononuclear cell morphology 127
              abnormal lymphocyte morphology 99
                abnormal T cell morphology 69
                  abnormal effector T cell morphology 23
                    abnormal CD4-positive, alpha beta T cell morphology 17
                      abnormal CD4-positive, alpha-beta T cell number 13
                        decreased CD4-positive, alpha-beta T cell number 8
                          decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 2
                            decreased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0
                            decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0
paths to the root