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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased brain cholesterol level
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Accession:MP:0010162 term browser browse the term
Definition:greater than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues


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increased brain cholesterol level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein IAGP MGI PMID:21303697 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Fuca1 fucosidase, alpha-L- 1, tissue IAGP MGI PMID:27491075 NCBI chr 4:135,648,037...135,667,611
Ensembl chr 4:135,648,046...135,667,622 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IAGP MGI PMID:23892605 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,129,296 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 IAGP MGI PMID:11138930 PMID:20007718 PMID:21303697 PMID:21856732 PMID:22048958 More... NCBI chr18:12,322,751...12,369,851
Ensembl chr18:12,322,749...12,369,457 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17275
    nervous system phenotype 4722
      abnormal nervous system morphology 3729
        abnormal brain morphology 2219
          abnormal brain cholesterol level 13
            increased brain cholesterol level 4
Path 2
Term Annotations click to browse term
  mammalian phenotype 17275
    homeostasis/metabolism phenotype 8085
      abnormal homeostasis 7204
        abnormal lipid homeostasis 2087
          abnormal lipid level 1957
            abnormal sterol level 1151
              increased sterol level 709
                increased brain sterol level 4
                  increased brain cholesterol level 4
paths to the root