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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:decreased DN4 thymocyte number
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Accession:MP:0010136 term browser browse the term
Definition:reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.
Comment:Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain.
Synonyms:exact_synonym: decreased DN4 alpha-beta immature T lymphocyte number;   decreased DN4 cell number;   decreased DN4 immature T cell number;   reduced DN4 alpha-beta immature T lymphocyte number;   reduced DN4 cell number;   reduced DN4 immature T cell number;   reduced DN4 thymocyte number
 xref: CL:0000808



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Term Annotations click to browse term
  mammalian phenotype 5370
    hematopoietic system phenotype 243
      abnormal hematopoietic system morphology/development 223
        abnormal thymus morphology 61
          decreased thymocyte number 9
            decreased DN4 thymocyte number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5370
    hematopoietic system phenotype 243
      abnormal hematopoietic system morphology/development 223
        abnormal hematopoietic cell morphology 179
          abnormal blood cell morphology 96
            abnormal hemopoiesis 18
              abnormal definitive hematopoiesis 18
                abnormal leukopoiesis 18
                  abnormal lymphopoiesis 18
                    abnormal T cell differentiation 18
                      abnormal double-negative T cell morphology 2
                        decreased double-negative T cell number 0
                          decreased DN4 thymocyte number 0
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