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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased circulating creatine kinase level
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Accession:MP:0010090 term browser browse the term
Definition:an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine
Comment:There is ambiguity in the literature regarding the terms creatinine kinase and creatine kinase. Most resources insist that creatine kinase is correct. See PMID:17174558 and PMID:14624200 not to mention Wikipedia. Creatine kinase is an enzyme found in the heart, brain, skeletal muscle, and other tissues. Increased amounts of CK are released into the blood when there is muscle damage. The small amount of CK that is normally in the blood comes primarily from skeletal muscles.
Synonyms:exact_synonym: elevated circulating CK level;   elevated circulating CPK level;   elevated circulating creatine kinase level;   elevated circulating creatine phosphokinase level;   elevated circulating creatinine kinase level;   elevated circulating phospho-creatine kinase level;   increased circulating CK level;   increased circulating CPK level;   increased circulating creatine phosphokinase level;   increased circulating creatinine kinase level;   increased circulating phospho-creatine kinase level


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increased circulating creatine kinase level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmd dystrophin IMP RGD PMID:25310701 RGD:12880034 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Dmdem1Ang dystrophin; TALEN-induced mutant1, Ang IMP RGD PMID:25310701 RGD:12880034
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5380
    homeostasis/metabolism phenotype 1404
      abnormal homeostasis 1305
        abnormal enzyme/coenzyme level 83
          abnormal creatine kinase level 8
            abnormal circulating creatine kinase level 3
              increased circulating creatine kinase level 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 5380
    homeostasis/metabolism phenotype 1404
      abnormal homeostasis 1305
        abnormal blood homeostasis 748
          abnormal circulating protein level 106
            abnormal circulating enzyme level 60
              abnormal circulating creatine kinase level 3
                increased circulating creatine kinase level 3
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