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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased circulating creatine kinase level
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Accession:MP:0010090 term browser browse the term
Definition:an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine
Comment:There is ambiguity in the literature regarding the terms creatinine kinase and creatine kinase. Most resources insist that creatine kinase is correct. See PMID:17174558 and PMID:14624200 not to mention Wikipedia. Creatine kinase is an enzyme found in the heart, brain, skeletal muscle, and other tissues. Increased amounts of CK are released into the blood when there is muscle damage. The small amount of CK that is normally in the blood comes primarily from skeletal muscles.
Synonyms:exact_synonym: elevated circulating CK level;   elevated circulating CPK level;   elevated circulating creatine kinase level;   elevated circulating creatine phosphokinase level;   elevated circulating creatinine kinase level;   elevated circulating phospho-creatine kinase level;   increased circulating CK level;   increased circulating CPK level;   increased circulating creatine phosphokinase level;   increased circulating creatinine kinase level;   increased circulating phospho-creatine kinase level


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increased circulating creatine kinase level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 IEA MGI NCBI chr11:7,013,433...7,128,506
Ensembl chr11:7,013,489...7,128,506 		JBrowse link
G Agl amylo-1,6-glucosidase, 4-alpha-glucanotransferase IAGP MGI PMID:24613482 PMID:25092169 NCBI chr 3:116,533,648...116,601,815
Ensembl chr 3:116,533,648...116,601,815 		JBrowse link
G Ano5 anoctamin 5 IAGP MGI PMID:26911675 PMID:30712070 NCBI chr 7:51,160,668...51,248,455
Ensembl chr 7:51,160,777...51,248,457 		JBrowse link
G Ap4e1 adaptor-related protein complex AP-4, epsilon 1 IEA MGI NCBI chr 2:126,850,600...126,911,734
Ensembl chr 2:126,850,637...126,909,829 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 IAGP MGI PMID:29908121 NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810 		JBrowse link
G Barx2 BarH-like homeobox 2 IEA MGI NCBI chr 9:31,757,340...31,824,581
Ensembl chr 9:31,757,340...31,824,758 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 (human) IAGP MGI PMID:16794820 NCBI chr 9:59,229,249...59,260,791
Ensembl chr 9:59,229,273...59,260,791 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 IEA MGI NCBI chr17:74,835,247...75,010,351
Ensembl chr17:74,835,290...75,010,351 		JBrowse link
G C1qtnf3 C1q and tumor necrosis factor related protein 3 IEA MGI NCBI chr15:10,952,418...10,980,248
Ensembl chr15:10,952,418...10,980,236 		JBrowse link
G Capn3 calpain 3 IAGP MGI PMID:20592470 NCBI chr 2:120,294,074...120,335,400
Ensembl chr 2:120,294,053...120,335,399 		JBrowse link
G Cav3 caveolin 3 IAGP MGI PMID:11259414 NCBI chr 6:112,436,466...112,449,833
Ensembl chr 6:112,436,466...112,449,833 		JBrowse link
G Cd300ld2 CD300 molecule like family member D2 IEA MGI NCBI chr11:114,901,146...114,907,657
Ensembl chr11:114,901,161...114,907,019 		JBrowse link
G Col4a1 collagen, type IV, alpha 1 IAGP MGI PMID:21625620 NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826 		JBrowse link
G Crppa CDP-L-ribitol pyrophosphorylase A IAGP MGI PMID:35422047 NCBI chr12:36,430,334...36,739,502
Ensembl chr12:36,431,449...36,739,502 		JBrowse link
G Ctss cathepsin S IAGP MGI PMID:26966179 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714 		JBrowse link
G Cul9 cullin 9 IEA MGI NCBI chr17:46,811,535...46,857,314
Ensembl chr17:46,811,498...46,857,314 		JBrowse link
G Dag1 dystroglycan 1 IAGP MGI PMID:12230980 PMID:22810924 NCBI chr 9:108,082,060...108,141,176
Ensembl chr 9:108,081,833...108,141,157 		JBrowse link
G Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 IAGP MGI PMID:29661920 NCBI chr 2:5,901,030...5,947,648
Ensembl chr 2:5,900,926...5,947,603 		JBrowse link
G Dmd dystrophin, muscular dystrophy IAGP MGI PMID:2967442 PMID:6583703 PMID:8064326 PMID:21145579 PMID:22810924 More... NCBI chr  X:81,858,244...84,248,656
Ensembl chr  X:81,992,476...84,249,747 		JBrowse link
G Dysf dysferlin IAGP MGI PMID:12736685 PMID:21060153 NCBI chr 6:83,985,344...84,188,042
Ensembl chr 6:83,985,572...84,188,042 		JBrowse link
G Epb41 erythrocyte membrane protein band 4.1 IAGP MGI PMID:9927493 NCBI chr 4:131,650,724...131,802,824
Ensembl chr 4:131,650,724...131,802,632 		JBrowse link
G Epc1 enhancer of polycomb homolog 1 IEA MGI NCBI chr18:6,435,951...6,516,108
Ensembl chr18:6,435,951...6,516,108 		JBrowse link
G Fkrp fukutin related protein IAGP MGI PMID:20675713 NCBI chr 7:16,543,192...16,550,657
Ensembl chr 7:16,543,171...16,550,657 		JBrowse link
G Fktn fukutin IAGP MGI PMID:22922256 PMID:23562821 NCBI chr 4:53,713,745...53,765,785
Ensembl chr 4:53,713,998...53,777,890 		JBrowse link
G Gbe1 glucan (1,4-alpha-), branching enzyme 1 IAGP MGI PMID:26385640 NCBI chr16:70,110,837...70,366,608
Ensembl chr16:70,110,837...70,366,604 		JBrowse link
G Ghr growth hormone receptor IAGP MGI PMID:15138153 NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974 		JBrowse link
G Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase IAGP MGI PMID:17164266 NCBI chr 4:44,034,075...44,084,177
Ensembl chr 4:44,034,075...44,084,177 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:31469588 PMID:31833196 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit IAGP MGI PMID:15328538 NCBI chr12:73,948,098...73,994,328
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hspb7 heat shock protein family, member 7 (cardiovascular) IAGP MGI PMID:26929074 NCBI chr 4:141,148,090...141,152,621
Ensembl chr 4:141,148,090...141,152,622 		JBrowse link
G Ighmbp2 immunoglobulin mu DNA binding protein 2 IAGP MGI PMID:15069027 NCBI chr19:3,309,076...3,333,011
Ensembl chr19:3,309,076...3,333,017 		JBrowse link
G Irf6 interferon regulatory factor 6 IEA MGI NCBI chr 1:192,835,420...192,854,344
Ensembl chr 1:192,835,419...192,854,331 		JBrowse link
G Itga7 integrin alpha 7 IAGP MGI PMID:9354797 NCBI chr10:128,769,633...128,794,155
Ensembl chr10:128,769,645...128,794,155 		JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 IAGP MGI PMID:7602333 NCBI chr 8:73,541,226...74,080,279
Ensembl chr 8:73,541,227...74,080,168 		JBrowse link
G Lmna lamin A IAGP MGI PMID:21818413 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
G Lrrk1 leucine-rich repeat kinase 1 IEA MGI NCBI chr 7:65,908,493...66,038,089
Ensembl chr 7:65,876,660...66,038,098 		JBrowse link
G Mpv17 MpV17 mitochondrial inner membrane protein IAGP MGI PMID:18818194 NCBI chr 5:31,298,007...31,311,595
Ensembl chr 5:31,297,998...31,311,595 		JBrowse link
G Mxra7 matrix-remodelling associated 7 IEA MGI NCBI chr11:116,694,226...116,718,953
Ensembl chr11:116,693,888...116,718,872 		JBrowse link
G Myf5 myogenic factor 5 IAGP MGI PMID:22922256 PMID:23562821 PMID:35422047 NCBI chr10:107,318,769...107,322,787
Ensembl chr10:107,318,769...107,321,995 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell IAGP MGI PMID:19036847 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Pdia4 protein disulfide isomerase associated 4 IEA MGI NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 IAGP MGI PMID:23630012 NCBI chr 9:105,520,156...105,564,854
Ensembl chr 9:105,520,177...105,564,856 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit IEA MGI NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Ptprm protein tyrosine phosphatase, receptor type, M IEA MGI NCBI chr17:66,973,843...67,661,486
Ensembl chr17:66,973,942...67,661,452 		JBrowse link
G Rnf168 ring finger protein 168 IEA MGI NCBI chr16:32,096,279...32,120,260
Ensembl chr16:32,096,277...32,120,252 		JBrowse link
G Rnf208 ring finger protein 208 IEA MGI NCBI chr 2:25,132,941...25,134,273
Ensembl chr 2:25,132,941...25,134,274 		JBrowse link
G Rps2 ribosomal protein S2 IAGP MGI PMID:34103648 NCBI chr17:24,939,037...24,940,901
Ensembl chr17:24,937,090...24,940,903 		JBrowse link
G Sbsn suprabasin IEA MGI NCBI chr 7:30,432,099...30,455,559
Ensembl chr 7:30,450,896...30,455,559 		JBrowse link
G Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein IAGP MGI PMID:31469588 NCBI chr 1:170,956,726...170,978,209
Ensembl chr 1:170,954,734...170,978,172 		JBrowse link
G Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) IAGP MGI PMID:9744877 PMID:18252746 PMID:28797108 NCBI chr11:94,853,603...94,867,153
Ensembl chr11:94,853,617...94,867,153 		JBrowse link
G Sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) IAGP MGI PMID:10862711 PMID:28797108 NCBI chr11:46,861,904...47,880,309
Ensembl chr11:46,787,080...47,879,796 		JBrowse link
G Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) IAGP MGI PMID:9732288 PMID:10485893 PMID:12609501 NCBI chr14:61,456,555...61,495,939
Ensembl chr14:61,456,564...61,495,939 		JBrowse link
G Sirt3 sirtuin 3 IEA MGI NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Slc28a3 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 IEA MGI NCBI chr13:58,701,121...58,758,691
Ensembl chr13:58,693,213...58,758,691 		JBrowse link
G Smn1 survival motor neuron 1 IAGP MGI PMID:11238465 NCBI chr13:100,259,713...100,274,206
Ensembl chr13:100,261,360...100,274,198 		JBrowse link
G Sptbn2 spectrin beta, non-erythrocytic 2 IEA MGI NCBI chr19:4,761,236...4,804,006
Ensembl chr19:4,761,195...4,802,388 		JBrowse link
G Sync syncoilin IAGP MGI PMID:18594912 NCBI chr 4:129,181,066...129,203,175
Ensembl chr 4:129,181,410...129,202,352 		JBrowse link
G Tcf20 transcription factor 20 IEA MGI NCBI chr15:82,692,648...82,872,304
Ensembl chr15:82,692,637...82,872,073 		JBrowse link
G Terc telomerase RNA component IAGP MGI PMID:21145579 NCBI chr 3:96,321,753...96,322,149
Ensembl chr 3:96,321,753...96,322,149 		JBrowse link
G Trpm1 transient receptor potential cation channel, subfamily M, member 1 IEA MGI NCBI chr 7:63,803,583...63,923,630
Ensembl chr 7:63,803,583...63,919,523 		JBrowse link
G Trub1 TruB pseudouridine (psi) synthase family member 1 IEA MGI NCBI chr19:57,441,323...57,479,437
Ensembl chr19:57,441,344...57,479,437 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase 3 IEA MGI NCBI chr 2:119,628,221...119,648,585
Ensembl chr 2:119,628,214...119,648,585 		JBrowse link
G Ubxn10 UBX domain protein 10 IEA MGI NCBI chr 4:138,437,148...138,465,749
Ensembl chr 4:138,437,148...138,464,478 		JBrowse link
G Zdhhc13 zinc finger, DHHC domain containing 13 IAGP MGI PMID:20548961 NCBI chr 7:48,438,751...48,477,188
Ensembl chr 7:48,438,751...48,477,188 		JBrowse link
G Zmpste24 zinc metallopeptidase, STE24 IAGP MGI PMID:11923874 NCBI chr 4:120,916,434...120,955,452
Ensembl chr 4:120,916,434...120,955,438 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16233
    homeostasis/metabolism phenotype 7358
      abnormal homeostasis 6527
        abnormal enzyme/coenzyme level 1357
          abnormal creatine kinase level 69
            abnormal circulating creatine kinase level 68
              increased circulating creatine kinase level 65
Path 2
Term Annotations click to browse term
  mammalian phenotype 16233
    homeostasis/metabolism phenotype 7358
      abnormal homeostasis 6527
        abnormal blood homeostasis 5012
          abnormal circulating protein level 1938
            abnormal circulating enzyme level 1254
              abnormal circulating creatine kinase level 68
                increased circulating creatine kinase level 65
paths to the root