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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal Sertoli cell phagocytosis
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Accession:MP:0009851 term browser browse the term
Definition:altered ability of the Sertoli cells to endocytose and degrade the apoptotic spermatogenic cells and residual bodies (shed cytoplasts) during the maturation phase of spermiogenesis; normally, greater than 50 per cent of differentiating spermatogenic cells undergo apoptosis before maturing into spermatozoa, and these cells are selectively and rapidly eliminated through phagocytosis by Sertoli cells



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  mammalian phenotype 5417
    reproductive system phenotype 129
      abnormal reproductive system morphology 97
        abnormal gametogenesis 20
          abnormal spermatogenesis 16
            abnormal spermiogenesis 8
              abnormal Sertoli cell phagocytosis 0
                decreased Sertoli cell phagocytosis 0
                increased Sertoli cell phagocytosis 0
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