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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal otic vesicle morphology
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Accession:MP:0009806 term browser browse the term
Definition:any structural anomaly of the paired sacs of invaginated ectoderm that develop into the membraneous labyrinth of the inner ear
Synonyms:exact_synonym: abnormal acoustic vesicle morphology;   abnormal auditory vesicle morphology;   abnormal otocyst morphology


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abnormal otic vesicle morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 IAGP MGI PMID:22319578 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525 		JBrowse link
G Alg10b asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase) IEA MGI NCBI chr15:90,108,514...90,114,757
Ensembl chr15:90,108,514...90,117,674 		JBrowse link
G Folr1 folate receptor 1 (adult) IEA MGI NCBI chr 7:101,507,551...101,519,974
Ensembl chr 7:101,507,538...101,519,995 		JBrowse link
G Hoxa1 homeobox A1 IAGP MGI PMID:8102800 NCBI chr 6:52,132,573...52,135,299
Ensembl chr 6:52,132,570...52,135,297 		JBrowse link
G Krit1 KRIT1, ankyrin repeat containing IEA MGI NCBI chr 5:3,853,156...3,894,515
Ensembl chr 5:3,853,184...3,895,564 		JBrowse link
G Pigq phosphatidylinositol glycan anchor biosynthesis, class Q IEA MGI NCBI chr17:26,145,398...26,161,855
Ensembl chr17:26,145,395...26,163,910 		JBrowse link
G Rdh10 retinol dehydrogenase 10 (all-trans) IAGP MGI PMID:17473173 PMID:21930923 PMID:22319578 NCBI chr 1:16,176,106...16,202,774
Ensembl chr 1:16,175,998...16,203,958 		JBrowse link
abnormal otic capsule development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mafb MAF bZIP transcription factor B IAGP MGI PMID:14207033 NCBI chr 2:160,205,597...160,208,985
Ensembl chr 2:160,205,623...160,208,985 		JBrowse link
abnormal otic vesicle development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 IAGP MGI PMID:10656767 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Chd7 chromodomain helicase DNA binding protein 7 IAGP MGI PMID:17334657 NCBI chr 4:8,690,345...8,868,449
Ensembl chr 4:8,690,406...8,867,659 		JBrowse link
G Csk c-src tyrosine kinase IAGP MGI PMID:8513497 NCBI chr 9:57,533,929...57,560,758
Ensembl chr 9:57,533,929...57,560,914 		JBrowse link
G Csnk2a1 casein kinase 2, alpha 1 polypeptide IAGP MGI PMID:17954558 NCBI chr 2:152,068,468...152,123,772
Ensembl chr 2:152,068,759...152,123,772 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 IAGP MGI PMID:10471511 PMID:16916509 NCBI chr 1:14,239,177...14,381,259
Ensembl chr 1:14,239,178...14,380,459 		JBrowse link
G Fbln1 fibulin 1 IAGP MGI PMID:18538758 NCBI chr15:85,090,150...85,170,495
Ensembl chr15:85,090,150...85,170,736 		JBrowse link
G Fgf10 fibroblast growth factor 10 IAGP MGI PMID:12810586 NCBI chr13:118,851,199...118,928,651
Ensembl chr13:118,806,327...118,928,651 		JBrowse link
G Fgf3 fibroblast growth factor 3 IAGP MGI PMID:12810586 NCBI chr 7:144,392,349...144,397,085
Ensembl chr 7:144,391,820...144,398,173 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IAGP MGI PMID:11180951 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
G Foxc2 forkhead box C2 IAGP MGI PMID:9409679 NCBI chr 8:121,842,910...121,845,634
Ensembl chr 8:121,842,910...121,845,634 		JBrowse link
G Gata3 GATA binding protein 3 IAGP MGI PMID:11135239 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gli3 GLI-Kruppel family member GLI3 IAGP MGI PMID:6049666 NCBI chr13:15,638,308...15,904,611
Ensembl chr13:15,637,820...15,904,611 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IAGP MGI PMID:11369229 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423 		JBrowse link
G Hoxa1 homeobox A1 IAGP MGI PMID:1346922 PMID:21784065 NCBI chr 6:52,132,573...52,135,299
Ensembl chr 6:52,132,570...52,135,297 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha IAGP MGI PMID:23226461 NCBI chr 1:167,515,864...167,676,310
Ensembl chr 1:167,516,806...167,676,310 		JBrowse link
G Mafb MAF bZIP transcription factor B IAGP MGI PMID:4758758 PMID:14207033 NCBI chr 2:160,205,597...160,208,985
Ensembl chr 2:160,205,623...160,208,985 		JBrowse link
G Pax3 paired box 3 IAGP MGI PMID:5912439 NCBI chr 1:78,077,904...78,173,773
Ensembl chr 1:78,077,904...78,173,771 		JBrowse link
G Rdh10 retinol dehydrogenase 10 (all-trans) IAGP MGI PMID:21305688 NCBI chr 1:16,176,106...16,202,774
Ensembl chr 1:16,175,998...16,203,958 		JBrowse link
G Rxra retinoid X receptor alpha IAGP MGI PMID:19255444 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Rxrb retinoid X receptor beta IAGP MGI PMID:19255444 NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373 		JBrowse link
G Shh sonic hedgehog IAGP MGI PMID:12231626 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254 		JBrowse link
G Six1 sine oculis-related homeobox 1 IAGP MGI PMID:14695375 PMID:19389353 NCBI chr12:73,088,601...73,093,486
Ensembl chr12:73,086,789...73,100,661 		JBrowse link
G Smo smoothened, frizzled class receptor IAGP MGI PMID:19854269 NCBI chr 6:29,735,480...29,761,359
Ensembl chr 6:29,735,502...29,761,364 		JBrowse link
G Vangl2 VANGL planar cell polarity 2 IAGP MGI PMID:11401449 NCBI chr 1:171,828,527...171,856,532
Ensembl chr 1:171,828,527...171,856,011 		JBrowse link
absent otic vesicle term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 IAGP MGI PMID:12810586 PMID:20171206 NCBI chr13:118,851,199...118,928,651
Ensembl chr13:118,806,327...118,928,651 		JBrowse link
G Fgf3 fibroblast growth factor 3 IAGP MGI PMID:12810586 PMID:20171206 NCBI chr 7:144,392,349...144,397,085
Ensembl chr 7:144,391,820...144,398,173 		JBrowse link
G Hesx1 homeobox gene expressed in ES cells IAGP MGI PMID:9620767 NCBI chr14:26,716,375...26,724,286
Ensembl chr14:26,716,373...26,724,286 		JBrowse link
G Nf1 neurofibromin 1 IAGP MGI PMID:7477259 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438 		JBrowse link
G Rasa1 RAS p21 protein activator 1 IAGP MGI PMID:7477259 NCBI chr13:85,362,893...85,437,487
Ensembl chr13:85,362,899...85,437,249 		JBrowse link
decreased otic epithelial cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 IAGP MGI PMID:16916509 NCBI chr 1:14,239,177...14,381,259
Ensembl chr 1:14,239,178...14,380,459 		JBrowse link
G Six1 sine oculis-related homeobox 1 IAGP MGI PMID:12834866 NCBI chr12:73,088,601...73,093,486
Ensembl chr12:73,086,789...73,100,661 		JBrowse link
increased otic epithelial cell apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 IAGP MGI PMID:10471511 PMID:16916509 NCBI chr 1:14,239,177...14,381,259
Ensembl chr 1:14,239,178...14,380,459 		JBrowse link
otic vesicle hypoplasia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 IAGP MGI PMID:10192400 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525 		JBrowse link
G Dlx5 distal-less homeobox 5 IAGP MGI PMID:12142028 NCBI chr 6:6,877,801...6,882,068
Ensembl chr 6:6,877,805...6,882,085 		JBrowse link
G Foxg1 forkhead box G1 IAGP MGI PMID:16600992 NCBI chr12:49,429,666...49,433,650
Ensembl chr12:49,429,443...49,433,644 		JBrowse link
G Tbx1 T-box 1 IAGP MGI PMID:15084464 PMID:16600992 NCBI chr16:18,399,729...18,409,412
Ensembl chr16:18,399,729...18,409,421 		JBrowse link
small otic vesicle term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 IAGP MGI PMID:11959834 PMID:22319578 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525 		JBrowse link
G Chd7 chromodomain helicase DNA binding protein 7 IAGP MGI PMID:17334657 NCBI chr 4:8,690,345...8,868,449
Ensembl chr 4:8,690,406...8,867,659 		JBrowse link
G Chrd chordin IAGP MGI PMID:12810603 NCBI chr16:20,551,528...20,561,132
Ensembl chr16:20,551,877...20,561,134 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 IAGP MGI PMID:16916509 NCBI chr 1:14,239,177...14,381,259
Ensembl chr 1:14,239,178...14,380,459 		JBrowse link
G Fgf10 fibroblast growth factor 10 IAGP MGI PMID:12810586 PMID:14623822 PMID:20171206 NCBI chr13:118,851,199...118,928,651
Ensembl chr13:118,806,327...118,928,651 		JBrowse link
G Fgf3 fibroblast growth factor 3 IAGP MGI PMID:12810586 PMID:14623822 PMID:20171206 NCBI chr 7:144,392,349...144,397,085
Ensembl chr 7:144,391,820...144,398,173 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IAGP MGI PMID:9435295 PMID:10934262 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
G Foxg1 forkhead box G1 IAGP MGI PMID:16600992 NCBI chr12:49,429,666...49,433,650
Ensembl chr12:49,429,443...49,433,644 		JBrowse link
G Gata3 GATA binding protein 3 IAGP MGI PMID:11135239 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gbx2 gastrulation brain homeobox 2 IAGP MGI PMID:9247335 PMID:15829521 NCBI chr 1:89,855,684...89,858,898
Ensembl chr 1:89,855,678...89,858,901 		JBrowse link
G Hoxa1 homeobox A1 IAGP MGI PMID:1346922 PMID:11528388 NCBI chr 6:52,132,573...52,135,299
Ensembl chr 6:52,132,570...52,135,297 		JBrowse link
G Lmo4 LIM domain only 4 IAGP MGI PMID:19913004 NCBI chr 3:143,894,291...143,911,016
Ensembl chr 3:143,894,291...143,910,981 		JBrowse link
G Ptch1 patched 1 IAGP MGI PMID:21305688 NCBI chr13:63,656,142...63,721,274
Ensembl chr13:63,656,142...63,721,412 		JBrowse link
G Rara retinoic acid receptor, alpha IAGP MGI PMID:7607067 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Rarg retinoic acid receptor, gamma IAGP MGI PMID:7607067 NCBI chr15:102,143,373...102,165,891
Ensembl chr15:102,143,373...102,165,952 		JBrowse link
G Rdh10 retinol dehydrogenase 10 (all-trans) IAGP MGI PMID:17473173 PMID:21930923 PMID:22319578 NCBI chr 1:16,176,106...16,202,774
Ensembl chr 1:16,175,998...16,203,958 		JBrowse link
G Tbx1 T-box 1 IAGP MGI PMID:11242110 PMID:12913075 PMID:15652707 PMID:16600992 NCBI chr16:18,399,729...18,409,412
Ensembl chr16:18,399,729...18,409,421 		JBrowse link
G Tcof1 treacle ribosome biogenesis factor 1 IAGP MGI PMID:10888597 NCBI chr18:60,946,827...60,982,055
Ensembl chr18:60,946,827...60,982,043 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16242
    hearing/vestibular/ear phenotype 981
      abnormal ear morphology 555
        abnormal ear development 74
          abnormal otic vesicle morphology 42
            abnormal otic vesicle development + 24
            absent otic vesicle 5
            decreased otic epithelial cell proliferation 2
            increased otic epithelial cell apoptosis 1
            small otic vesicle + 19
paths to the root