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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal stratum corneum lipid matrix formation
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Accession:MP:0009596 term browser browse the term
Definition:altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae
Synonyms:exact_synonym: abnormal intercorneocyte lamellar lipids;   abnormal intercorneocyte lipid lamellae;   abnormal stratum corneum extracellular lipid matrix;   defective epidermal lipid matrix composition;   epidermal lipid matrix defects

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  mammalian phenotype 5400
    integument phenotype 168
      abnormal skin morphology 16
        abnormal epidermal layer morphology 2
          abnormal epidermis stratum corneum morphology 2
            abnormal stratum corneum lipid matrix formation 0
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