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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal cumulus expansion
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Accession:MP:0009373 term browser browse the term
Definition:anomaly in the ability of the cumulus cells to synthesize and accumulate hyaluronan into an extracellular matrix (ECM), which provides an essential microenvironment for oocyte fertilization; this expanded ECM binds the oocyte and the cumulus cells together, protects the oocyte from the proteolytic and mechanical stresses during extrusion, and allows sperm binding, penetration, and fertilization
Synonyms:exact_synonym: abnormal ovarian cumulus expansion;   abnormal ovarian cumulus growth



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abnormal cumulus expansion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amhr2 anti-Mullerian hormone type 2 receptor IAGP MGI PMID:16513794 PMID:18809571 NCBI chr15:102,353,437...102,363,075
Ensembl chr15:102,353,802...102,363,068
JBrowse link
G Ptger2 prostaglandin E receptor 2 (subtype EP2) IAGP MGI PMID:9751056 NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IAGP MGI PMID:10342859 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Smad2 SMAD family member 2 IAGP MGI PMID:18809571 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034
JBrowse link
G Smad3 SMAD family member 3 IAGP MGI PMID:18809571 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276
JBrowse link
G Smad4 SMAD family member 4 IAGP MGI PMID:16513794 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851
JBrowse link
absent cumulus expansion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambp alpha 1 microglobulin/bikunin precursor IAGP MGI PMID:11145954 NCBI chr 4:63,061,512...63,072,409
Ensembl chr 4:63,061,512...63,073,036
JBrowse link
G Amhr2 anti-Mullerian hormone type 2 receptor IAGP MGI PMID:16513794 NCBI chr15:102,353,437...102,363,075
Ensembl chr15:102,353,802...102,363,068
JBrowse link
G Bmp15 bone morphogenetic protein 15 IAGP MGI PMID:11376106 NCBI chr  X:6,226,108...6,232,778
Ensembl chr  X:6,226,161...6,232,775
JBrowse link
G Bmpr1b bone morphogenetic protein receptor, type 1B IAGP MGI PMID:11416163 NCBI chr 3:141,540,230...141,875,335
Ensembl chr 3:141,542,897...141,875,186
JBrowse link
G Gdf9 growth differentiation factor 9 IAGP MGI PMID:11376106 NCBI chr11:53,321,773...53,328,731
Ensembl chr11:53,321,850...53,328,731
JBrowse link
G Ptger2 prostaglandin E receptor 2 (subtype EP2) IAGP MGI PMID:10468638 NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277
JBrowse link
G Ptx3 pentraxin related gene IAGP MGI PMID:12040004 PMID:14998931 PMID:17675295 NCBI chr 3:66,127,308...66,133,227
Ensembl chr 3:66,127,331...66,133,226
JBrowse link
G Smad4 SMAD family member 4 IAGP MGI PMID:16513794 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 IAGP MGI PMID:12668637 NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698
JBrowse link
decreased cumulus expansion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pabpc1l poly(A) binding protein, cytoplasmic 1-like IAGP MGI PMID:22621333 NCBI chr 2:163,866,685...163,892,458
Ensembl chr 2:163,867,370...163,892,458
JBrowse link
increased cumulus expansion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Efna5 ephrin A5 IAGP MGI PMID:26672804 NCBI chr17:62,909,949...63,188,431
Ensembl chr17:62,911,179...63,188,312
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16659
    reproductive system phenotype 3343
      abnormal reproductive system morphology 2449
        abnormal sex gland morphology 1625
          abnormal female reproductive gland morphology 533
            abnormal ovary morphology 491
              abnormal ovarian follicle morphology 279
                abnormal ovarian folliculogenesis 138
                  abnormal cumulus expansion 14
                    absent cumulus expansion 9
                    decreased cumulus expansion 1
                    increased cumulus expansion 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 16659
    reproductive system phenotype 3343
      abnormal reproductive system morphology 2449
        abnormal female reproductive system morphology 889
          abnormal female genitalia morphology 886
            abnormal internal female genitalia morphology 878
              abnormal ovary morphology 491
                abnormal ovarian follicle morphology 279
                  abnormal ovarian folliculogenesis 138
                    abnormal cumulus expansion 14
                      absent cumulus expansion 9
                      decreased cumulus expansion 1
                      increased cumulus expansion 1
paths to the root