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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal pancreatic ghrelin secretion
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Accession:MP:0009196 term browser browse the term
Definition:anomaly in the production and/or regulated release from pancreatic epsilon cells of a 28-amino acid, acylated, orexigenic peptide that acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis; it is cleaved from a large precursor protein, known as appetite-regulating hormone or motilin-related peptide, which contains both ghrelin and obestatin
Comment:Ghrelin-secreting cells are found mainly in the stomach and duodenum, but also in the jejunum, lungs, pancreatic islets, gonads, adrenal cortex, placenta, kidney and brain.


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  mammalian phenotype 5417
    endocrine/exocrine gland phenotype 394
      abnormal gland physiology 85
        abnormal pancreas physiology 67
          abnormal endocrine pancreas physiology 28
            abnormal pancreatic epsilon cell physiology 0
              abnormal pancreatic ghrelin secretion 0
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