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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:decreased prepulse inhibition
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Accession:MP:0009142 term browser browse the term
Definition:decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus
Synonyms:exact_synonym: decreased PPI;   reduced PPI;   reduced prepulse inhibition



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decreased prepulse inhibition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nlgn3 neuroligin 3 IMP RGD PMID:24773431 PMID:28958035 RGD:9831152, RGD:126790492 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876
JBrowse link
G Nlgn3em1Sage neuroligin 3; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24773431 PMID:28958035 RGD:9831152, RGD:126790492
G Nrg1 neuregulin 1 sexual_dimorphism IMP compared to wild type female RGD PMID:21620900 RGD:405650204 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nrg1Tn(sb-T2/Bart3)2.183Mcwi neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin sexual_dimorphism IMP compared to wild type female RGD PMID:21620900 RGD:405650204
G Pax6 paired box 6 IAGP DNA:frameshift mutation:cds: RGD PMID:21203536 RGD:8552339 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link

Term paths to the root
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  mammalian phenotype 5420
    nervous system phenotype 376
      abnormal nervous system physiology 218
        abnormal synaptic physiology 47
          abnormal synaptic transmission 46
            abnormal CNS synaptic transmission 42
              abnormal prepulse inhibition 20
                decreased prepulse inhibition 7
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