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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal fat cell morphology
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Accession:MP:0009115 term browser browse the term
Definition:any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals
Synonyms:exact_synonym: abnormal adipocyte morphology;   abnormal lipocyte morphology
 alt_id: MP:0004128


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abnormal fat cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator-activated receptor gamma IAGP RGD PMID:27381370 RGD:127285618 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargm1Kyo peroxisome proliferator-activated receptor gamma; ENU induced mutant 1, Kyo IAGP RGD PMID:27381370 RGD:127285618
decreased fat cell size term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angptl8 angiopoietin-like 8 IMP compared to wild type rats RGD PMID:30042156 RGD:38549347 NCBI chr 8:28,652,555...28,654,581
Ensembl chr 8:28,652,555...28,654,581 		JBrowse link
G Angptl8em1Kyo angiopoietin-like 8; CRISPR/Cas9 induced mutant 1, Kyo IMP compared to wild type rats RGD PMID:30042156 RGD:38549347
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 IMP compared to wild type RGD PMID:26077568 RGD:13800514 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812 		JBrowse link
G Hsd11b2em1Jmul hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul IMP compared to wild type RGD PMID:26077568 RGD:13800514
decreased white fat cell size term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pmch pro-melanin-concentrating hormone IMP RGD PMID:23555928 RGD:150429944 NCBI chr 7:24,399,404...24,400,720
Ensembl chr 7:24,399,404...24,400,720 		JBrowse link
G Pmchm1Hubr pro-melanin-concentrating hormone; ENU induced mutant1, Hubr IMP RGD PMID:23555928 RGD:150429944
increased fat cell size term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 induces IMP compared to standard diet and wild type RGD PMID:29656108 RGD:150520032 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Cyp2j4em1Sage cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage induces IMP compared to standard diet and wild type RGD PMID:29656108 RGD:150520032
G Lepr leptin receptor IMP RGD PMID:27225180 PMID:26537785 RGD:12910507, RGD:12911216 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Leprem3 leptin receptor; TALEN induced mutant 3 IMP RGD PMID:27225180 RGD:12910507
G Leprem4Lizh leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh IMP RGD PMID:26537785 RGD:12911216
G Mc4r melanocortin 4 receptor IMP RGD PMID:21527895 RGD:6478803 NCBI chr18:62,689,798...62,691,685 JBrowse link
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr IMP RGD PMID:21527895 RGD:6478803
G Pparg peroxisome proliferator-activated receptor gamma IAGP RGD PMID:27381370 RGD:127285618 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargm1Kyo peroxisome proliferator-activated receptor gamma; ENU induced mutant 1, Kyo IAGP RGD PMID:27381370 RGD:127285618
increased white fat cell number term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor IAGP compared to age-matched lean heterozygous +/fa rats RGD PMID:9843879 RGD:628910 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Leprfa leptin receptor; fa mutant IAGP compared to age-matched lean heterozygous +/fa rats RGD PMID:9843879 RGD:628910
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5432
    adipose tissue phenotype 135
      abnormal adipose tissue morphology 129
        abnormal fat cell morphology 29
          abnormal beige fat cell morphology 0
          abnormal brown fat cell morphology + 0
          abnormal fat cell differentiation + 3
          abnormal fat cell mitochondrial morphology + 0
          abnormal white fat cell morphology + 6
          decreased fat cell size + 9
          increased fat cell size + 18
paths to the root