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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal xenobiotic pharmacokinetics
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Accession:MP:0008875 term browser browse the term
Definition:any anomaly in the absorption, distribution, metabolism or elimination of a compound foreign to living organisms
Synonyms:exact_synonym: abnormal pharmacokinetics of xenobiotics


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abnormal xenobiotic pharmacokinetics term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IMP compared to wildtype control, CHEBI:6532|CHEBI:4551|CHEBI:40050|CHEBI:28593|CHEBI:8364|CHEBI:45783|CHEBI:9948|CHEBI:3723 RGD PMID:22711747 PMID:24398459 RGD:14392811, RGD:150429695 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1aem1Sage ATP binding cassette subfamily B member 1A; ZFN induced mutant 1, Sage IMP compared to wildtype control, CHEBI:6532|CHEBI:4551|CHEBI:40050|CHEBI:28593|CHEBI:8364|CHEBI:45783|CHEBI:9948|CHEBI:3723
compared to wildtype controls, CHEBI:45863|CHEBI:6532|CHEBI:51619		 RGD PMID:24398459 PMID:22711747 RGD:150429695, RGD:14392811
G Abcc2 ATP binding cassette subfamily C member 2 IMP RGD PMID:22711747 RGD:14392811 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc2em1Sage ATP binding cassette subfamily C member 2; ZFN induced mutant 1, Sage IMP compared to wildtype controls, CHEBI:9334|CHEBI:45863|CHEBI:51619 RGD PMID:22711747 RGD:14392811
G Abcg2 ATP binding cassette subfamily G member 2 IMP RGD PMID:22711747 RGD:14392811 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abcg2em1Sage ATP-binding cassette, subfamily G (WHITE), member 2; ZFN induced mutatn 1, Sage IMP compared to wildtype controls, CHEBI:9334|CHEBI:51619 RGD PMID:22711747 RGD:14392811
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 sexual_dimorphism IAGP
IMP		 compared between male and female
compared to wild type		 RGD PMID:29444903 PMID:29444903 RGD:150429710, RGD:150429710 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c11em1Nju cytochrome P450, subfamily 2, polypeptide 11; CRISPR/Cas9 induced mutant 1, Nju sexual_dimorphism IAGP
IMP		 compared between male and female
compared to wild type		 RGD PMID:29444903 PMID:29444903 RGD:150429710, RGD:150429710
G Slco1b2 solute carrier organic anion transporter family member 1B2 IMP RGD PMID:32528832 RGD:150521535 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco1b2em1Myliu solute carrier organic anion transporter family member 1B2; CRISPR/Case9 induced mutant 1, Myliu IMP RGD PMID:32528832 RGD:150521535
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  mammalian phenotype 5420
    homeostasis/metabolism phenotype 1426
      abnormal xenobiotic pharmacokinetics 16
        abnormal xenobiotic metabolism + 0
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