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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal spleen physiology
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Accession:MP:0008737 term browser browse the term
Definition:any functional anomaly of the organ that filters blood and stores red corpuscles and platelets
Synonyms:broad_synonym: Abnormality of the spleen
 xref: HP:0001743


show annotations for term's descendants           Sort by:
abnormal spleen physiology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 (alpha) IAGP MGI PMID:14745006 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Foxn1 forkhead box N1 IAGP MGI PMID:4929778 NCBI chr11:78,248,403...78,277,597
Ensembl chr11:78,248,403...78,277,384 		JBrowse link
G Gba1 glucosylceramidase beta 1 IAGP MGI PMID:11994410 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273 		JBrowse link
G Lig1 ligase I, DNA, ATP-dependent IAGP MGI PMID:12124343 NCBI chr 7:13,011,101...13,045,351
Ensembl chr 7:13,011,239...13,045,350 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 IAGP MGI PMID:15210949 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Setd7 SET domain containing (lysine methyltransferase) 7 IAGP MGI PMID:18280244 NCBI chr 3:51,422,740...51,468,519
Ensembl chr 3:51,422,740...51,468,300 		JBrowse link
G Sirt6 sirtuin 6 IAGP MGI PMID:20847051 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 IAGP MGI PMID:15342464 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683 		JBrowse link
abnormal splenocyte apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp9 caspase 9 IAGP MGI PMID:9708736 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
abnormal splenocyte physiology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase IAGP MGI PMID:8806812 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239 		JBrowse link
G Akap13 A kinase anchor protein 13 IAGP MGI PMID:19211510 NCBI chr 7:75,105,271...75,404,357
Ensembl chr 7:75,105,282...75,404,357 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 IAGP MGI PMID:11163212 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bax BCL2-associated X protein IAGP MGI PMID:11163212 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 IAGP MGI PMID:10811868 NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984 		JBrowse link
G Cd99 CD99 antigen IAGP MGI PMID:22350746
G Csf1 colony stimulating factor 1 (macrophage) IAGP MGI PMID:8045348 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 IAGP MGI PMID:11035773 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IAGP MGI PMID:12600915 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Fam210b family with sequence similarity 210, member B IAGP MGI PMID:39000360 NCBI chr 2:172,187,444...172,197,669
Ensembl chr 2:172,187,485...172,197,669 		JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb IAGP MGI PMID:17997333 NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116 		JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha IAGP MGI PMID:8398989 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797 		JBrowse link
G Ibtk inhibitor of Bruton agammaglobulinemia tyrosine kinase IAGP MGI PMID:21482705 NCBI chr 9:85,569,412...85,632,756
Ensembl chr 9:85,569,413...85,631,387 		JBrowse link
G Il13 interleukin 13 IAGP MGI PMID:10679097 PMID:11745342 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il4 interleukin 4 IAGP MGI PMID:10679097 PMID:11745342 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 IAGP MGI PMID:23997217 NCBI chr 6:128,386,407...128,401,873
Ensembl chr 6:128,386,407...128,401,894 		JBrowse link
G Ncstn nicastrin IAGP MGI PMID:23359070 NCBI chr 1:171,893,580...171,910,356
Ensembl chr 1:171,893,580...171,910,362 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 IAGP MGI PMID:15210949 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain IAGP MGI PMID:20715164 NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497 		JBrowse link
G Rcbtb2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 IAGP MGI PMID:26291700 NCBI chr14:73,376,185...73,421,495
Ensembl chr14:73,360,477...73,445,283 		JBrowse link
G Tlr7 toll-like receptor 7 IAGP MGI PMID:17997333 NCBI chr  X:166,086,376...166,113,570
Ensembl chr  X:166,087,925...166,113,554 		JBrowse link
G Tyk2 tyrosine kinase 2 IAGP MGI PMID:11070174 NCBI chr 9:21,015,364...21,042,689
Ensembl chr 9:21,015,364...21,042,539 		JBrowse link
abnormal splenocyte proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain IAGP MGI PMID:12925853 NCBI chr 7:140,671,088...140,680,493
Ensembl chr 7:140,671,088...140,680,485 		JBrowse link
decreased splenocyte apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 IAGP MGI PMID:19651893 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l11 BCL2 like 11 IAGP MGI PMID:19651893 PMID:26563351 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 IAGP MGI PMID:15680327 NCBI chr13:38,829,667...38,843,004
Ensembl chr13:38,828,183...38,843,034 		JBrowse link
G Klf13 Kruppel-like transcription factor 13 IAGP MGI PMID:17442931 NCBI chr 7:63,536,099...63,588,663
Ensembl chr 7:63,536,099...63,588,663 		JBrowse link
G Mlf1 myeloid leukemia factor 1 IAGP MGI PMID:26563351 NCBI chr 3:67,281,430...67,307,333
Ensembl chr 3:67,281,430...67,307,336 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IAGP MGI PMID:21079150 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 IAGP MGI PMID:16675958 NCBI chr 2:165,834,557...165,915,162
Ensembl chr 2:165,834,545...165,915,162 		JBrowse link
G Steap3 STEAP family member 3 IAGP MGI PMID:18617898 NCBI chr 1:120,154,137...120,198,810
Ensembl chr 1:120,118,487...120,200,435 		JBrowse link
G Trp53 transformation related protein 53 IAGP MGI PMID:23166633 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
decreased splenocyte proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex2 apurinic/apyrimidinic endonuclease 2 IAGP MGI PMID:15319281 NCBI chr  X:149,286,625...149,371,175
Ensembl chr  X:149,302,515...149,372,864 		JBrowse link
G Bmi1 Bmi1 polycomb ring finger oncogene IAGP MGI PMID:7926765 NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440 		JBrowse link
G Cbx2 chromobox 2 IAGP MGI PMID:9043087 NCBI chr11:118,913,845...118,922,101
Ensembl chr11:118,913,788...118,922,096 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IAGP MGI PMID:11015448 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Cd247 CD247 antigen IAGP MGI PMID:8223495 NCBI chr 1:165,607,514...165,698,722
Ensembl chr 1:165,616,250...165,704,846 		JBrowse link
G Cd28 CD28 antigen IAGP MGI PMID:12752681 PMID:15024044 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Chi3l1 chitinase 3 like 1 IAGP MGI PMID:19414556 NCBI chr 1:134,109,894...134,117,769
Ensembl chr 1:134,109,914...134,117,919 		JBrowse link
G Crlf2 cytokine receptor-like factor 2 IAGP MGI PMID:16172260 NCBI chr 5:109,702,575...109,707,301
Ensembl chr 5:109,702,575...109,706,859 		JBrowse link
G Ctc1 CTS telomere maintenance complex component 1 IAGP MGI PMID:22531781 NCBI chr11:68,906,014...68,927,299
Ensembl chr11:68,906,737...68,927,299 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IAGP MGI PMID:11907072 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 IAGP MGI PMID:12944494 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
G Il10ra interleukin 10 receptor, alpha IAGP MGI PMID:22711892 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447 		JBrowse link
G Impdh1 inosine monophosphate dehydrogenase 1 IAGP MGI PMID:12944494 NCBI chr 6:29,200,435...29,216,363
Ensembl chr 6:29,200,433...29,216,363 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 IAGP MGI PMID:12944494 NCBI chr 9:108,437,635...108,442,776
Ensembl chr 9:108,437,485...108,442,783 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IAGP MGI PMID:21079150 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Nmt1 N-myristoyltransferase 1 IAGP MGI PMID:26423150 NCBI chr11:102,919,163...102,959,734
Ensembl chr11:102,919,016...102,959,738 		JBrowse link
G Nmt2 N-myristoyltransferase 2 IAGP MGI PMID:26423150 NCBI chr 2:3,285,249...3,329,914
Ensembl chr 2:3,285,249...3,329,914 		JBrowse link
G Ntan1 N-terminal Asn amidase IAGP MGI PMID:10805755 NCBI chr16:13,636,629...13,653,314
Ensembl chr16:13,636,709...13,653,315 		JBrowse link
G Prkcq protein kinase C, theta IAGP MGI PMID:15024044 PMID:16493044 NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 IAGP MGI PMID:12855817 NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786 		JBrowse link
G Tlr2 toll-like receptor 2 IAGP MGI PMID:17353199 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr7 toll-like receptor 7 IAGP MGI PMID:17997333 NCBI chr  X:166,086,376...166,113,570
Ensembl chr  X:166,087,925...166,113,554 		JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 IAGP MGI PMID:12752681 NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559 		JBrowse link
G Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 IAGP MGI PMID:12070288 NCBI chr17:57,496,437...57,501,182
Ensembl chr17:57,496,492...57,501,177 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor IAGP MGI PMID:11697802 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
increased splenocyte apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl AXL receptor tyrosine kinase IAGP MGI PMID:10227296 NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 IAGP MGI PMID:19651893 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Braf Braf transforming gene IAGP MGI PMID:21383153 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Ets1 E26 avian leukemia oncogene 1, 5' domain IAGP MGI PMID:17339335 NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116 		JBrowse link
G Mertk MER proto-oncogene tyrosine kinase IAGP MGI PMID:10227296 NCBI chr 2:128,540,836...128,645,082
Ensembl chr 2:128,540,876...128,644,814 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 IAGP MGI PMID:15210949 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 IAGP MGI PMID:9432976 NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824 		JBrowse link
G Polb polymerase (DNA directed), beta IAGP MGI PMID:22493258 PMID:24388753 NCBI chr 8:23,118,135...23,143,482
Ensembl chr 8:23,118,142...23,143,451 		JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 IAGP MGI PMID:15342464 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683 		JBrowse link
G Srrt serrate RNA effector molecule homolog (Arabidopsis) IAGP MGI PMID:19632182 NCBI chr 5:137,293,966...137,306,564
Ensembl chr 5:137,293,973...137,305,928 		JBrowse link
G Tlx1 T cell leukemia, homeobox 1 IAGP MGI PMID:7555717 NCBI chr19:45,138,531...45,145,382
Ensembl chr19:45,139,119...45,145,382 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase 3 IAGP MGI PMID:10227296 NCBI chr 2:119,628,123...119,648,585
Ensembl chr 2:119,628,214...119,648,585 		JBrowse link
G Usp4 ubiquitin specific peptidase 4 (proto-oncogene) IAGP MGI PMID:21522127 NCBI chr 9:108,223,763...108,269,744
Ensembl chr 9:108,225,052...108,269,744 		JBrowse link
G Wt1 WT1 transcription factor IAGP MGI PMID:10469569 NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961 		JBrowse link
increased splenocyte proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton agammaglobulinemia tyrosine kinase IAGP MGI PMID:2884254 NCBI chr  X:133,443,083...133,484,366
Ensembl chr  X:133,443,085...133,484,319 		JBrowse link
G Ccne1 cyclin E1 IAGP MGI PMID:16023597 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cd28 CD28 antigen IAGP MGI PMID:12752681 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A IAGP MGI PMID:11544531 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 IAGP MGI PMID:15680327 NCBI chr13:38,829,667...38,843,004
Ensembl chr13:38,828,183...38,843,034 		JBrowse link
G Espl1 extra spindle pole bodies 1, separase IAGP MGI PMID:21799785 NCBI chr15:102,204,688...102,232,792
Ensembl chr15:102,204,701...102,232,792 		JBrowse link
G Flg filaggrin IAGP MGI PMID:19349982 NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993 		JBrowse link
G Hmox1 heme oxygenase 1 IAGP MGI PMID:19398754 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Ifng interferon gamma IAGP MGI PMID:8456300 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ifngr1 interferon gamma receptor 1 IAGP MGI PMID:15902435 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Igh immunoglobulin heavy chain complex IAGP MGI PMID:19573810 NCBI chr12:113,222,388...115,973,574 JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:14699048 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:19398754 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Mdm4 transformed mouse 3T3 cell double minute 4 IAGP MGI PMID:19573810 NCBI chr 1:132,913,843...132,958,325
Ensembl chr 1:132,887,222...132,958,299 		JBrowse link
G Oprm1 opioid receptor, mu 1 IAGP MGI PMID:9126934 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
G Pomc pro-opiomelanocortin-alpha IAGP MGI PMID:12458044 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 IAGP MGI PMID:2884254 NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Rnf128 ring finger protein 128 IAGP MGI PMID:20493730 NCBI chr  X:138,464,089...138,573,894
Ensembl chr  X:138,464,065...138,573,894 		JBrowse link
G Timd4 T cell immunoglobulin and mucin domain containing 4 IAGP MGI PMID:20368430 NCBI chr11:46,701,613...46,735,160
Ensembl chr11:46,701,627...46,735,159 		JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 IAGP MGI PMID:12752681 NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559 		JBrowse link
G Trp53 transformation related protein 53 IAGP MGI PMID:21411755 PMID:21799785 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 17065
    immune system phenotype 5763
      abnormal immune system physiology 3496
        abnormal immune organ physiology 218
          abnormal spleen physiology 93
            abnormal splenocyte physiology + 87
paths to the root