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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased lung non-small cell carcinoma incidence
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Accession:MP:0008716 term browser browse the term
Definition:greater than the expected number of a heterogeneous aggregate of at least three distinct histological types of lung cancer, occurring in a specific population in a given time period
Synonyms:related_synonym: lung non-small cell carcinoma


show annotations for term's descendants           Sort by:
increased lung non-small cell carcinoma incidence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf Braf transforming gene IAGP MGI PMID:21514245 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Cdk6 cyclin dependent kinase 6 IAGP MGI PMID:20609353 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G E2f1 E2F transcription factor 1 IAGP MGI PMID:8653789 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:20609353 PMID:20832755 PMID:21514245 PMID:22611036 PMID:22964582 More... NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 IAGP MGI PMID:21514245 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 IAGP MGI PMID:21514245 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 IAGP MGI PMID:21514245 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 IAGP MGI PMID:21514245 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 IAGP MGI PMID:23453624 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898 		JBrowse link
G Polr2a polymerase (RNA) II (DNA directed) polypeptide A IAGP MGI PMID:20609353 NCBI chr11:69,624,823...69,649,459
Ensembl chr11:69,624,823...69,649,463 		JBrowse link
G Scrib scribbled planar cell polarity IAGP MGI PMID:24276238 NCBI chr15:75,919,011...75,941,633
Ensembl chr15:75,919,007...75,941,633 		JBrowse link
G Trp53 transformation related protein 53 IAGP MGI PMID:22611036 PMID:22964582 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
increased lung adenocarcinoma incidence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abraxas1 BRCA1 A complex subunit IAGP MGI PMID:25066119 NCBI chr 5:100,952,668...100,968,816
Ensembl chr 5:100,953,058...100,968,831 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 IAGP MGI PMID:21901109 NCBI chr11:79,980,205...80,026,623
Ensembl chr11:79,980,226...80,026,620 		JBrowse link
G Becn1 beclin 1, autophagy related IAGP MGI PMID:14638851 PMID:14657337 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bin3 bridging integrator 3 IAGP MGI PMID:18339847 NCBI chr14:70,337,538...70,375,413
Ensembl chr14:70,337,554...70,375,655 		JBrowse link
G Braf Braf transforming gene IAGP MGI PMID:17299132 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase IAGP MGI PMID:23878276 NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B IAGP MGI PMID:17409423 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A IAGP MGI PMID:11751631 PMID:16015333 PMID:17676035 PMID:21118965 PMID:23565506 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C IAGP MGI PMID:17409423 NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386 		JBrowse link
G Dmtf1 cyclin D binding myb like transcription factor 1 IAGP MGI PMID:17936562 NCBI chr 5:9,168,868...9,211,782
Ensembl chr 5:9,168,801...9,211,776 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 IAGP MGI PMID:23604072 NCBI chr10:62,782,762...62,809,967
Ensembl chr10:62,782,805...62,809,964 		JBrowse link
G Dnai7 dynein axonemal intermediate chain 7 IAGP MGI PMID:16862160 NCBI chr 6:145,120,556...145,156,866
Ensembl chr 6:145,120,560...145,156,731 		JBrowse link
G Dok1 docking protein 1 IAGP MGI PMID:20139980 NCBI chr 6:83,007,915...83,010,448
Ensembl chr 6:83,007,915...83,010,452 		JBrowse link
G Dok2 docking protein 2 IAGP MGI PMID:20139980 NCBI chr14:71,003,336...71,015,934
Ensembl chr14:71,003,476...71,015,935 		JBrowse link
G Dok3 docking protein 3 IAGP MGI PMID:20139980 NCBI chr13:55,671,044...55,678,158
Ensembl chr13:55,671,044...55,677,109 		JBrowse link
G E2f1 E2F transcription factor 1 IAGP MGI PMID:8653789 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Eaf2 ELL associated factor 2 IAGP MGI PMID:17873910 NCBI chr16:36,613,246...36,695,275
Ensembl chr16:36,613,246...36,695,365 		JBrowse link
G Fen1 flap structure specific endonuclease 1 IAGP MGI PMID:17589521 NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533 		JBrowse link
G Fntb farnesyltransferase, CAAX box, beta IAGP MGI PMID:15837621 NCBI chr12:76,884,014...76,968,188
Ensembl chr12:76,812,363...76,968,186 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha IAGP MGI PMID:16141330 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Gprc5a G protein-coupled receptor, family C, group 5, member A IAGP MGI PMID:18000218 NCBI chr 6:135,042,660...135,061,707
Ensembl chr 6:135,042,649...135,061,707 		JBrowse link
G Gpx7 glutathione peroxidase 7 IAGP MGI PMID:23123197 NCBI chr 4:108,257,414...108,263,910
Ensembl chr 4:108,257,587...108,264,158 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:19064922 PMID:20548776 PMID:22430205 PMID:22863881 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Hck hemopoietic cell kinase IAGP MGI PMID:12208875 NCBI chr 2:152,950,388...152,993,361
Ensembl chr 2:152,950,388...152,993,361 		JBrowse link
G Hic1 hypermethylated in cancer 1 IAGP MGI PMID:12539045 NCBI chr11:75,052,203...75,059,970
Ensembl chr11:75,055,391...75,060,345 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 IAGP MGI PMID:19064922 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
G Ifng interferon gamma IAGP MGI PMID:12093877 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:11323676 PMID:12957286 PMID:15837621 PMID:16288016 PMID:16288213 More... NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Lmo7 LIM domain only 7 IAGP MGI PMID:19215226 NCBI chr14:101,967,353...102,172,144
Ensembl chr14:101,967,386...102,172,146 		JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:17476360 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Lzts1 leucine zipper, putative tumor suppressor 1 IAGP MGI PMID:17349584 NCBI chr 8:69,585,311...69,636,901
Ensembl chr 8:69,585,321...69,636,877 		JBrowse link
G Mad1l1 MAD1 mitotic arrest deficient 1-like 1 IAGP MGI PMID:17210695 NCBI chr 5:139,994,444...140,307,346
Ensembl chr 5:139,994,444...140,307,307 		JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 IAGP MGI PMID:11201745 NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204 		JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 IAGP MGI PMID:21317887 NCBI chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 IAGP MGI PMID:17468755 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 IAGP MGI PMID:17143284 NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264 		JBrowse link
G Men1 multiple endocrine neoplasia 1 IAGP MGI PMID:11158604 PMID:17409423 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Msh2 mutS homolog 2 IAGP MGI PMID:15126346 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141 		JBrowse link
G Mutyh mutY DNA glycosylase IAGP MGI PMID:15126346 NCBI chr 4:116,664,846...116,676,641
Ensembl chr 4:116,664,920...116,676,637 		JBrowse link
G Nbn nibrin IAGP MGI PMID:14612522 NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589 		JBrowse link
G Nf1 neurofibromin 1 IAGP MGI PMID:7920653 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438 		JBrowse link
G Nf2 neurofibromin 2 IAGP MGI PMID:9553042 PMID:10887156 PMID:15221010 NCBI chr11:4,715,845...4,799,544
Ensembl chr11:4,715,845...4,799,536 		JBrowse link
G Nudt1 nudix hydrolase 1 IAGP MGI PMID:11572992 NCBI chr 5:140,307,375...140,323,892
Ensembl chr 5:140,307,411...140,323,892 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 IAGP MGI PMID:15126346 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Pcbp4 poly(rC) binding protein 4 IAGP MGI PMID:26915821 NCBI chr 9:106,330,181...106,341,211
Ensembl chr 9:106,330,490...106,341,211 		JBrowse link
G Pggt1b protein geranylgeranyltransferase type I, beta subunit IAGP MGI PMID:17476360 NCBI chr18:46,368,411...46,414,173
Ensembl chr18:46,368,418...46,414,060 		JBrowse link
G Plk3 polo like kinase 3 IAGP MGI PMID:18519666 NCBI chr 4:116,985,852...116,991,244
Ensembl chr 4:116,985,852...116,991,160 		JBrowse link
G Pold1 polymerase (DNA directed), delta 1, catalytic subunit IAGP MGI PMID:11385474 NCBI chr 7:44,182,168...44,198,239
Ensembl chr 7:44,182,170...44,198,273 		JBrowse link
G Polr2a polymerase (RNA) II (DNA directed) polypeptide A IAGP MGI PMID:15837621 PMID:17468755 NCBI chr11:69,624,823...69,649,459
Ensembl chr11:69,624,823...69,649,463 		JBrowse link
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha IAGP MGI PMID:21791616 NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178 		JBrowse link
G Prdm2 PR domain containing 2, with ZNF domain IAGP MGI PMID:11544182 NCBI chr 4:142,833,961...142,939,560
Ensembl chr 4:142,833,961...142,939,565 		JBrowse link
G Prdx1 peroxiredoxin 1 IAGP MGI PMID:12891360 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019 		JBrowse link
G Prf1 perforin 1 (pore forming protein) IAGP MGI PMID:12093877 NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459 		JBrowse link
G Pten phosphatase and tensin homolog IAGP MGI PMID:17909629 PMID:18281487 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Rassf5 Ras association (RalGDS/AF-6) domain family member 5 IAGP MGI PMID:21194982 NCBI chr 1:131,104,147...131,172,915
Ensembl chr 1:131,104,147...131,172,995 		JBrowse link
G Rb1 RB transcriptional corepressor 1 IAGP MGI PMID:14522252 PMID:19151761 PMID:19765830 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 IAGP MGI PMID:19151761 NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472 		JBrowse link
G Rint1 RAD50 interactor 1 IAGP MGI PMID:17470549 NCBI chr 5:23,992,700...24,028,582
Ensembl chr 5:23,992,709...24,025,367 		JBrowse link
G Rnf7 ring finger protein 7 IAGP MGI PMID:24430184 NCBI chr 9:96,352,990...96,360,728
Ensembl chr 9:96,352,990...96,360,728 		JBrowse link
G Robo1 roundabout guidance receptor 1 IAGP MGI PMID:15374951 NCBI chr16:71,824,406...72,844,379
Ensembl chr16:72,105,194...72,842,983 		JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 IAGP MGI PMID:18281487 PMID:20548776 NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322 		JBrowse link
G Sclt1 sodium channel and clathrin linker 1 IAGP MGI PMID:16015333 NCBI chr 3:41,581,140...41,696,968
Ensembl chr 3:41,581,155...41,696,949 		JBrowse link
G Scrib scribbled planar cell polarity IAGP MGI PMID:21965329 NCBI chr15:75,919,011...75,941,633
Ensembl chr15:75,919,007...75,941,633 		JBrowse link
G Sftpc surfactant associated protein C IAGP MGI PMID:23285300 NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521 		JBrowse link
G Smg1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase IAGP MGI PMID:23277562 NCBI chr 7:117,730,531...117,843,026
Ensembl chr 7:117,730,531...117,842,893 		JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 IAGP MGI PMID:20739274 NCBI chr11:30,049,395...30,218,384
Ensembl chr11:30,049,395...30,218,175 		JBrowse link
G Srpx sushi-repeat-containing protein IAGP MGI PMID:17088259 NCBI chr  X:9,904,216...9,983,879
Ensembl chr  X:9,904,216...9,983,948 		JBrowse link
G Stk11 serine/threonine kinase 11 IAGP MGI PMID:17676035 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Tgfbi transforming growth factor, beta induced IAGP MGI PMID:19117985 NCBI chr13:56,757,399...56,787,172
Ensembl chr13:56,757,336...56,787,375 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II IAGP MGI PMID:21911454 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Thbs1 thrombospondin 1 IAGP MGI PMID:11696456 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Tnk1 tyrosine kinase, non-receptor, 1 IAGP MGI PMID:18974114 NCBI chr11:69,741,389...69,749,556
Ensembl chr11:69,741,831...69,749,556 		JBrowse link
G Tpx2 TPX2, microtubule-associated IAGP MGI PMID:22266221 NCBI chr 2:152,689,859...152,737,241
Ensembl chr 2:152,689,884...152,737,241 		JBrowse link
G Trim62 tripartite motif-containing 62 IAGP MGI PMID:23838884 NCBI chr 4:128,777,837...128,805,119
Ensembl chr 4:128,777,373...128,805,121 		JBrowse link
G Trp53 transformation related protein 53 IAGP MGI PMID:11696456 PMID:11751631 PMID:14522252 PMID:15607980 PMID:15837625 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trp63 transformation related protein 63 IAGP MGI PMID:15837625 NCBI chr16:25,502,513...25,710,842
Ensembl chr16:25,502,513...25,710,852 		JBrowse link
G Trp73 transformation related protein 73 IAGP MGI PMID:15837625 PMID:18805989 NCBI chr 4:154,140,706...154,224,332
Ensembl chr 4:154,140,706...154,224,665 		JBrowse link
G Xpa xeroderma pigmentosum, complementation group A IAGP MGI PMID:10837020 NCBI chr 4:46,175,222...46,196,317
Ensembl chr 4:46,155,347...46,196,311 		JBrowse link
G Xpc xeroderma pigmentosum, complementation group C IAGP MGI PMID:16141330 NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870 		JBrowse link
increased lung large cell carcinoma incidence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:17676035 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Stk11 serine/threonine kinase 11 IAGP MGI PMID:17676035 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
increased lung squamous cell carcinoma incidence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chuk conserved helix-loop-helix ubiquitous kinase IAGP MGI PMID:23597566 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:17676035 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 IAGP MGI PMID:27335465 NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 IAGP MGI PMID:27335465 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Pten phosphatase and tensin homolog IAGP MGI PMID:17909629 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Stk11 serine/threonine kinase 11 IAGP MGI PMID:17676035 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16965
    respiratory system phenotype 1866
      abnormal respiratory system morphology 1287
        increased respiratory system tumor incidence 167
          increased lung tumor incidence 167
            increased lung carcinoma incidence 112
              increased lung non-small cell carcinoma incidence 94
                increased lung adenocarcinoma incidence 85
                increased lung large cell carcinoma incidence 2
                increased lung squamous cell carcinoma incidence 6
Path 2
Term Annotations click to browse term
  mammalian phenotype 16965
    neoplasm 1358
      abnormal tumor susceptibility 1215
        abnormal tumor incidence 1194
          increased tumor incidence 1021
            increased classified tumor incidence 736
              increased malignant tumor incidence 442
                increased carcinoma incidence 344
                  increased lung carcinoma incidence 112
                    increased lung non-small cell carcinoma incidence 94
                      increased lung adenocarcinoma incidence 85
                      increased lung large cell carcinoma incidence 2
                      increased lung squamous cell carcinoma incidence 6
paths to the root