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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased circulating interleukin-1 beta level
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Accession:MP:0008641 term browser browse the term
Definition:increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane
Synonyms:exact_synonym: increased circulating IL-1 beta level;   increased circulating IL-1b level;   increased circulating Il1b level;   increased circulating catabloin level


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increased circulating interleukin-1 beta level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S LA-cp/NJcr IAGP compared to lean LA/NJcr+/+ rats RGD PMID:17375078 RGD:1642389
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5420
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal immune serum protein physiology 92
          abnormal cytokine level 39
            abnormal interleukin level 23
              abnormal circulating interleukin level 23
                abnormal circulating interleukin-1 level 2
                  increased circulating interleukin-1 level 1
                    increased circulating interleukin-1 beta level 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    homeostasis/metabolism phenotype 1423
      abnormal homeostasis 1324
        abnormal protein level 137
          abnormal intercellular signaling peptide or protein level 43
            abnormal cytokine level 39
              abnormal interleukin level 23
                abnormal circulating interleukin level 23
                  increased circulating interleukin level 13
                    increased circulating interleukin-1 level 1
                      increased circulating interleukin-1 beta level 1
paths to the root