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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased circulating interleukin-1 beta level
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Accession:MP:0008641 term browser browse the term
Definition:increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane
Synonyms:exact_synonym: increased circulating IL-1 beta level;   increased circulating IL-1b level;   increased circulating Il1b level;   increased circulating catabloin level
 narrow_synonym: Abnormal serum interleukin level
 xref: HP:0030782


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increased circulating interleukin-1 beta level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamdec1 ADAM-like, decysin 1 IAGP MGI PMID:27226416 NCBI chr14:68,800,829...68,819,535
Ensembl chr14:68,800,829...68,819,544 		JBrowse link
G Atg16l1 autophagy related 16 like 1 IAGP MGI PMID:23973919 PMID:24553140 NCBI chr 1:87,683,730...87,720,150
Ensembl chr 1:87,683,592...87,720,150 		JBrowse link
G Atg5 autophagy related 5 IAGP MGI PMID:27096368 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Atg7 autophagy related 7 IAGP MGI PMID:27096368 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G Becn1 beclin 1, autophagy related IAGP MGI PMID:27096368 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Brd2 bromodomain containing 2 IAGP MGI PMID:19883376 NCBI chr17:34,330,993...34,341,581
Ensembl chr17:34,330,997...34,341,608 		JBrowse link
G Btrc beta-transducin repeat containing protein IAGP MGI PMID:24469832 NCBI chr19:45,352,119...45,521,782
Ensembl chr19:45,352,173...45,518,452 		JBrowse link
G C3ar1 complement component 3a receptor 1 IAGP MGI PMID:11067891 PMID:15383607 NCBI chr 6:122,824,099...122,833,116
Ensembl chr 6:122,824,097...122,833,120 		JBrowse link
G Colgalt2 collagen beta(1-O)galactosyltransferase 2 IAGP MGI PMID:30355948 NCBI chr 1:152,275,485...152,386,942
Ensembl chr 1:152,275,581...152,386,446 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 IAGP MGI PMID:20042581 NCBI chr10:84,967,564...85,020,918
Ensembl chr10:84,967,564...85,020,928 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 IAGP MGI PMID:20042581 NCBI chr 2:92,233,991...92,264,426
Ensembl chr 2:92,233,991...92,264,388 		JBrowse link
G Ctse cathepsin E IAGP MGI PMID:14769879 NCBI chr 1:131,566,052...131,603,245
Ensembl chr 1:131,566,044...131,603,243 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide IAGP MGI PMID:27096368 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Dusp11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) IAGP MGI PMID:32796023 NCBI chr 6:85,919,250...85,938,950
Ensembl chr 6:85,919,250...85,938,649 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 IAGP MGI PMID:22201685 NCBI chr 8:4,334,781...4,375,104
Ensembl chr 8:4,335,382...4,375,413 		JBrowse link
G Fbxw11 F-box and WD-40 domain protein 11 IAGP MGI PMID:24469832 NCBI chr11:32,592,595...32,696,816
Ensembl chr11:32,592,724...32,696,816 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:23293022 PMID:24498102 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,055,336 		JBrowse link
G Hmgb1 high mobility group box 1 IAGP MGI PMID:24302768 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Ifngr1 interferon gamma receptor 1 IAGP MGI PMID:31964735 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Il10 interleukin 10 IAGP MGI PMID:18650318 PMID:19941312 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il10ra interleukin 10 receptor, alpha IAGP MGI PMID:19941312 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447 		JBrowse link
G Il1r1 interleukin 1 receptor, type I IAGP MGI PMID:11994477 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417 		JBrowse link
G Il27ra interleukin 27 receptor, alpha IAGP MGI PMID:15004160 NCBI chr 8:84,756,915...84,769,250
Ensembl chr 8:84,756,923...84,769,218 		JBrowse link
G Lacc1 laccase domain containing 1 IAGP MGI PMID:27478939 NCBI chr14:77,261,640...77,274,344
Ensembl chr14:77,261,640...77,274,344 		JBrowse link
G Ldlr low density lipoprotein receptor IAGP MGI PMID:18410513 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lif leukemia inhibitory factor IAGP MGI PMID:9651226 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IAGP MGI PMID:23940344 NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122 		JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:19501000 PMID:19941312 PMID:22201685 PMID:22348103 PMID:24302768 More... NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 IAGP MGI PMID:22348103 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mefv Mediterranean fever IAGP MGI PMID:21600797 NCBI chr16:3,524,838...3,536,073
Ensembl chr16:3,525,082...3,535,961 		JBrowse link
G Mep1a meprin 1 alpha IAGP MGI PMID:19262505 NCBI chr17:43,785,215...43,815,034
Ensembl chr17:43,785,215...43,813,703 		JBrowse link
G Mir146 microRNA 146 IAGP MGI PMID:21555486 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 IAGP MGI PMID:17349961 NCBI chr 2:165,834,557...165,915,162
Ensembl chr 2:165,834,545...165,915,162 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 IAGP MGI PMID:12101242 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 IAGP MGI PMID:19501000 PMID:22558291 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 IAGP MGI PMID:22396549 NCBI chr13:75,237,407...75,282,980
Ensembl chr13:75,237,945...75,282,980 		JBrowse link
G Prf1 perforin 1 (pore forming protein) IAGP MGI PMID:23160464 NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 IAGP MGI PMID:21435452 NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family IAGP MGI PMID:23160464 NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911 		JBrowse link
G Rag1 recombination activating 1 IAGP MGI PMID:21600797 NCBI chr 2:101,468,597...101,479,877
Ensembl chr 2:101,468,627...101,479,846 		JBrowse link
G Rubcn RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein IAGP MGI PMID:27096368 NCBI chr16:32,642,072...32,698,121
Ensembl chr16:32,642,073...32,698,136 		JBrowse link
G Sectm1a secreted and transmembrane 1A IAGP MGI PMID:32170929 NCBI chr11:120,958,221...120,988,023
Ensembl chr11:120,958,233...120,972,046 		JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 IAGP MGI PMID:26596471 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 IAGP MGI PMID:22562833 NCBI chr10:95,219,765...95,253,176
Ensembl chr10:95,221,224...95,253,042 		JBrowse link
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 IAGP MGI PMID:24302768 NCBI chr13:3,199,475...3,239,678
Ensembl chr13:3,236,206...3,239,317
Ensembl chr13:3,236,206...3,239,317 		JBrowse link
G St18 suppression of tumorigenicity 18 IAGP MGI PMID:32668247 NCBI chr 1:6,557,455...6,931,164
Ensembl chr 1:6,557,455...6,931,164 		JBrowse link
G Stx11 syntaxin 11 IAGP MGI PMID:23160464 NCBI chr10:12,813,961...12,840,242
Ensembl chr10:12,813,953...12,840,042 		JBrowse link
G Tbk1 TANK-binding kinase 1 IAGP MGI PMID:20651301 NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692 		JBrowse link
G Thbd thrombomodulin IAGP MGI PMID:11557684 PMID:12208873 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Timd4 T cell immunoglobulin and mucin domain containing 4 IAGP MGI PMID:27096368 NCBI chr11:46,701,613...46,735,160
Ensembl chr11:46,701,627...46,735,159 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 IAGP MGI PMID:24498102 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Tnfaip8l2 tumor necrosis factor, alpha-induced protein 8-like 2 IAGP MGI PMID:18455983 NCBI chr 3:95,046,832...95,051,581
Ensembl chr 3:95,046,832...95,049,671 		JBrowse link
G Trim31 tripartite motif-containing 31 IAGP MGI PMID:27929086 NCBI chr17:37,209,022...37,221,109
Ensembl chr17:37,209,010...37,221,106 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 IAGP MGI PMID:30662948 NCBI chr  X:95,290,807...95,337,044
Ensembl chr  X:95,290,809...95,337,044 		JBrowse link
G Yod1 YOD1 deubiquitinase IAGP MGI PMID:38789414 NCBI chr 1:130,645,064...130,652,093
Ensembl chr 1:130,645,064...130,652,095 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17065
    immune system phenotype 5763
      abnormal immune system physiology 3496
        abnormal immune serum protein physiology 1479
          abnormal cytokine level 606
            abnormal interleukin level 401
              abnormal circulating interleukin level 345
                abnormal circulating interleukin-1 level 94
                  increased circulating interleukin-1 level 64
                    increased circulating interleukin-1 beta level 55
Path 2
Term Annotations click to browse term
  mammalian phenotype 17065
    homeostasis/metabolism phenotype 7909
      abnormal homeostasis 7051
        abnormal protein level 2371
          abnormal intercellular signaling peptide or protein level 621
            abnormal cytokine level 606
              abnormal interleukin level 401
                abnormal circulating interleukin level 345
                  increased circulating interleukin level 227
                    increased circulating interleukin-1 level 64
                      increased circulating interleukin-1 beta level 55
paths to the root