Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased circulating interleukin-23 level
go back to main search page
Accession:MP:0008620 term browser browse the term
Definition:increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells
Comment:Interleukin-23 is comprised of a unique 19 kDa subunit (IL-23a) and 40 kDa subunit (IL-12b) that is shared with interleukin-12.
Synonyms:exact_synonym: increased circulating IL-23 level;   increased circulating IL23 level


show annotations for term's descendants           Sort by:
increased circulating interleukin-23 level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4a2 C-type lectin domain family 4, member a2 IAGP MGI PMID:18204462 NCBI chr 6:123,099,627...123,119,891
Ensembl chr 6:123,083,387...123,120,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16963
    immune system phenotype 5709
      abnormal immune system physiology 3489
        abnormal immune serum protein physiology 1475
          abnormal cytokine level 605
            abnormal interleukin level 400
              abnormal circulating interleukin level 344
                abnormal circulating interleukin-23 level 1
                  increased circulating interleukin-23 level 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 16963
    homeostasis/metabolism phenotype 7866
      abnormal homeostasis 7016
        abnormal protein level 2351
          abnormal intercellular signaling peptide or protein level 620
            abnormal cytokine level 605
              abnormal circulating cytokine level 456
                abnormal circulating interleukin level 344
                  abnormal circulating interleukin-23 level 1
                    increased circulating interleukin-23 level 1
paths to the root