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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:decreased circulating interleukin-12 level
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Accession:MP:0008618 term browser browse the term
Definition:reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells
Comment:Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa (IL-12b) and 35 kDa (IL-12a) subunits. The 40 kDa subunit (IL-12b) also is a component of interleukin-23 together with the IL-23a ( 19kDa) chain.
Synonyms:exact_synonym: decreased circulating IL-12 level;   decreased circulating IL-12 p70 level;   decreased circulating IL12 level;   decreased circulating cytotoxic lymphocyte maturation factor level;   decreased circulating interleukin-12 p70 level;   decreased circulating natural killer cell stimulatory factor level;   reduced circulating IL-12 level;   reduced circulating IL-12 p70 level;   reduced circulating IL12 level;   reduced circulating cytotoxic lymphocyte maturation factor level;   reduced circulating interleukin-12 p70 level;   reduced circulating natural killer cell stimulatory factor level



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Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    immune system phenotype 519
      abnormal immune system physiology 384
        abnormal immune serum protein physiology 92
          abnormal cytokine level 39
            abnormal interleukin level 23
              abnormal circulating interleukin level 23
                abnormal circulating interleukin-12 level 0
                  decreased circulating interleukin-12 level 0
                    decreased circulating interleukin-12a level 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    homeostasis/metabolism phenotype 1423
      abnormal homeostasis 1324
        abnormal protein level 137
          abnormal intercellular signaling peptide or protein level 43
            abnormal cytokine level 39
              abnormal circulating cytokine level 29
                abnormal circulating interleukin level 23
                  abnormal circulating interleukin-12 level 0
                    decreased circulating interleukin-12 level 0
                      decreased circulating interleukin-12a level 0
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