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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:decreased circulating interleukin-6 level
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Accession:MP:0008597 term browser browse the term
Definition:reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts
Synonyms:exact_synonym: decreased circulating B cell stimulatory factor-2 level;   decreased circulating B-cell differentiation factor level;   decreased circulating B-cell differentiation factor-2 level;   decreased circulating BSF-2 level;   decreased circulating IFN-beta 2 level;   decreased circulating IL-6 level;   decreased circulating IL6 level;   decreased circulating MGI-2 level;   decreased circulating hepatocyte-stimulating factor level;   decreased circulating hybridoma growth factor level;   decreased circulating myeloid differentiation-inducing protein level;   decreased circulating plasmacytoma growth factor level;   reduced circulating B-cell differentiation factor level;   reduced circulating B-cell differentiation factor-2 level;   reduced circulating B-cell stimulatory factor-2 level;   reduced circulating BSF-2 level;   reduced circulating IFN-beta 2 level;   reduced circulating IL-6 level;   reduced circulating IL6 level;   reduced circulating MGI-2 level;   reduced circulating hepatocyte-stimulating factor level;   reduced circulating hybridoma growth factor level;   reduced circulating myeloid differentiation-inducing protein level;   reduced circulating plasmacytoma growth factor level



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decreased circulating interleukin-6 level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IAGP MGI PMID:16403440 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Apoe apolipoprotein E IAGP MGI PMID:19347044 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G Arid5a AT rich interactive domain 5A (MRF1-like) IAGP MGI PMID:23676272 NCBI chr 1:36,346,814...36,363,117
Ensembl chr 1:36,346,814...36,363,110
JBrowse link
G AW112010 expressed sequence AW112010 IAGP MGI PMID:30542152 NCBI chr19:11,024,976...11,027,930
Ensembl chr19:11,021,557...11,033,245
JBrowse link
G Bbs12 Bardet-Biedl syndrome 12 (human) IAGP MGI PMID:22958920 NCBI chr 3:37,366,695...37,383,334
Ensembl chr 3:37,366,703...37,375,602
JBrowse link
G C3 complement component 3 IAGP MGI PMID:19620784 PMID:20709903 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G C3ar1 complement component 3a receptor 1 IAGP MGI PMID:20709903 NCBI chr 6:122,824,099...122,833,116
Ensembl chr 6:122,824,097...122,833,120
JBrowse link
G C5ar1 complement component 5a receptor 1 IAGP MGI PMID:20709903 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465
JBrowse link
G Casp1 caspase 1 IAGP MGI PMID:7859282 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase IAGP MGI PMID:7859282 NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Cd14 CD14 antigen IAGP MGI PMID:8612135 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
JBrowse link
G Cd19 CD19 antigen IAGP MGI PMID:18467694 PMID:23509369 NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061
JBrowse link
G Clic4 chloride intracellular channel 4 (mitochondrial) IAGP MGI PMID:21469130 NCBI chr 4:134,941,280...135,000,071
Ensembl chr 4:134,941,280...135,000,125
JBrowse link
G Ctsc cathepsin C IAGP MGI PMID:18292580 NCBI chr 7:87,927,220...87,965,069
Ensembl chr 7:87,927,293...87,960,096
JBrowse link
G Cxcl5 chemokine (C-X-C motif) ligand 5 IAGP MGI PMID:20643340 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 IEA MGI NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288
JBrowse link
G F3 coagulation factor III IAGP MGI PMID:15215187 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Foxn1 forkhead box N1 IAGP MGI PMID:9820556 NCBI chr11:78,248,403...78,277,597
Ensembl chr11:78,248,403...78,277,384
JBrowse link
G Foxp3 forkhead box P3 IAGP MGI PMID:17581588 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484
JBrowse link
G Gba glucosidase, beta, acid IAGP MGI PMID:20962279 NCBI chr 3:89,110,223...89,116,180
Ensembl chr 3:89,110,235...89,116,273
JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:24339869 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294
JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 IAGP MGI PMID:29920190 NCBI chr 4:116,852,491...116,862,474
Ensembl chr 4:116,852,514...116,862,474
JBrowse link
G Hspb8 heat shock protein 8 IAGP MGI PMID:21747053 NCBI chr 5:116,546,550...116,560,923
Ensembl chr 5:116,546,550...116,560,923
JBrowse link
G Ifi204 interferon activated gene 204 IAGP MGI PMID:29472103 NCBI chr 1:173,574,859...173,594,606
Ensembl chr 1:173,574,859...173,594,509
JBrowse link
G Ifi35 interferon-induced protein 35 IAGP MGI PMID:29038465 NCBI chr11:101,339,238...101,349,527
Ensembl chr11:101,339,233...101,349,524
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 IAGP MGI PMID:24014876 NCBI chr19:34,527,961...34,553,934
Ensembl chr19:34,528,094...34,553,819
JBrowse link
G Il18 interleukin 18 IAGP MGI PMID:18573894 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1r1 interleukin 1 receptor, type I IAGP MGI PMID:9278338 PMID:9317135 PMID:11994477 PMID:19347044 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417
JBrowse link
G Il6 interleukin 6 IAGP MGI PMID:17581588 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Il6st interleukin 6 signal transducer IAGP MGI PMID:21148800 NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 IAGP MGI PMID:19224918 NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987
JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 IAGP MGI PMID:11923871 PMID:17470642 NCBI chr15:94,441,495...94,466,198
Ensembl chr15:94,441,524...94,479,696
JBrowse link
G Irf5 interferon regulatory factor 5 IAGP MGI PMID:15665823 NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870
JBrowse link
G Klhdc10 kelch domain containing 10 IAGP MGI PMID:27631783 NCBI chr 6:30,401,516...30,455,178
Ensembl chr 6:30,401,867...30,455,178
JBrowse link
G Lrrc19 leucine rich repeat containing 19 IAGP MGI PMID:25026888 NCBI chr 4:94,523,958...94,538,381
Ensembl chr 4:94,524,890...94,538,381
JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:18423196 PMID:22573811 PMID:31189603 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226
JBrowse link
G Mavs mitochondrial antiviral signaling protein IAGP MGI PMID:16785313 PMID:18178804 NCBI chr 2:131,075,445...131,089,945
Ensembl chr 2:131,075,983...131,089,945
JBrowse link
G Msmp microseminoprotein, prostate associated IAGP MGI PMID:31813573 NCBI chr 4:43,583,216...43,584,494
Ensembl chr 4:43,583,216...43,584,494
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 IAGP MGI PMID:18656388 PMID:22586041 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta IAGP MGI PMID:20740013 NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937
JBrowse link
G Nmi N-myc (and STAT) interactor IAGP MGI PMID:29038465 NCBI chr 2:51,838,510...51,863,505
Ensembl chr 2:51,838,499...51,863,506
JBrowse link
G Nmu neuromedin U IAGP MGI PMID:19070594 NCBI chr 5:76,481,342...76,511,624
Ensembl chr 5:76,481,342...76,511,635
JBrowse link
G Peli1 pellino 1 IAGP MGI PMID:19734906 NCBI chr11:21,041,283...21,100,327
Ensembl chr11:21,041,291...21,100,323
JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 IAGP MGI PMID:15340057 NCBI chr17:32,631,433...32,643,157
Ensembl chr17:32,631,433...32,643,141
JBrowse link
G Pilrb1 paired immunoglobin-like type 2 receptor beta 1 IAGP MGI PMID:20065029 NCBI chr 5:137,850,403...137,856,687
Ensembl chr 5:137,850,409...137,856,368
JBrowse link
G Plekhf1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 IAGP MGI PMID:31189603 NCBI chr 7:37,920,078...37,927,418
Ensembl chr 7:37,916,396...37,927,440
JBrowse link
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit IAGP MGI PMID:19892703 NCBI chr 5:116,151,645...116,162,596
Ensembl chr 5:116,151,645...116,162,567
JBrowse link
G Ptgs2os prostaglandin-endoperoxide synthase 2, opposite strand IAGP MGI PMID:35365562 NCBI chr 1:149,950,624...149,975,625
Ensembl chr 1:149,950,624...149,975,714
JBrowse link
G Retnlb resistin like beta IAGP MGI PMID:27397737 NCBI chr16:48,637,219...48,639,255
Ensembl chr16:48,637,219...48,639,255
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 IAGP MGI PMID:15869599 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Sgms1 sphingomyelin synthase 1 IAGP MGI PMID:22580896 NCBI chr19:32,100,127...32,367,285
Ensembl chr19:32,100,127...32,367,114
JBrowse link
G Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin IAGP MGI PMID:22851711 NCBI chr 2:130,911,140...130,928,697
Ensembl chr 2:130,911,140...130,928,685
JBrowse link
G Slc15a4 solute carrier family 15, member 4 IAGP MGI PMID:21277849 NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961
JBrowse link
G Spp1 secreted phosphoprotein 1 IAGP MGI PMID:17823662 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Stat3 signal transducer and activator of transcription 3 IAGP MGI PMID:21148800 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 IAGP MGI PMID:21813776 NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607
JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 IAGP MGI PMID:23509369 NCBI chr10:7,781,412...7,832,039
Ensembl chr10:7,781,417...7,831,994
JBrowse link
G Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 IAGP MGI PMID:23509369 NCBI chr  X:84,617,466...84,678,075
Ensembl chr  X:84,617,628...84,678,075
JBrowse link
G Thbd thrombomodulin IAGP MGI PMID:22573811 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 IAGP MGI PMID:18178804 PMID:18423196 NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786
JBrowse link
G Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein IAGP MGI PMID:21148800 NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587
JBrowse link
G Tlr4 toll-like receptor 4 IAGP MGI PMID:18423196 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor IAGP MGI PMID:9426403 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a IAGP MGI PMID:18719121 PMID:20457915 PMID:23676465 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
JBrowse link
G Tollip toll interacting protein IAGP MGI PMID:16428431 NCBI chr 7:141,435,317...141,456,198
Ensembl chr 7:141,428,550...141,472,244
JBrowse link
G Tradd TNFRSF1A-associated via death domain IAGP MGI PMID:18719121 NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241
JBrowse link
G Traf6 TNF receptor-associated factor 6 IAGP MGI PMID:18423196 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014
JBrowse link
G Txndc2 thioredoxin domain containing 2 (spermatozoa) IEA MGI NCBI chr17:65,944,500...65,955,871
Ensembl chr17:65,944,502...65,949,163
JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator IAGP MGI PMID:24778236 NCBI chr19:3,985,171...3,999,340
Ensembl chr19:3,985,186...3,999,340
JBrowse link
G Usp20 ubiquitin specific peptidase 20 IAGP MGI PMID:30814308 NCBI chr 2:30,872,291...30,912,667
Ensembl chr 2:30,872,291...30,913,598
JBrowse link
G Zcchc3 zinc finger, CCHC domain containing 3 IAGP MGI PMID:30135424 NCBI chr 2:152,253,876...152,256,964
Ensembl chr 2:152,253,875...152,256,947
JBrowse link
G Zdhhc1 zinc finger, DHHC domain containing 1 IAGP MGI PMID:25299331 NCBI chr 8:106,199,055...106,223,694
Ensembl chr 8:106,199,055...106,223,534
JBrowse link
G Zdhhc11 zinc finger, DHHC domain containing 11 IAGP MGI PMID:34490261 NCBI chr13:74,111,970...74,141,109
Ensembl chr13:74,111,970...74,141,109
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16084
    immune system phenotype 5300
      abnormal immune system physiology 3339
        abnormal immune serum protein physiology 1417
          abnormal cytokine level 565
            abnormal interleukin level 375
              abnormal circulating interleukin level 326
                abnormal circulating interleukin-6 level 198
                  decreased circulating interleukin-6 level 73
Path 2
Term Annotations click to browse term
  mammalian phenotype 16084
    homeostasis/metabolism phenotype 7265
      abnormal homeostasis 6445
        abnormal protein level 2080
          abnormal intercellular signaling peptide or protein level 580
            abnormal cytokine level 565
              abnormal circulating cytokine level 432
                abnormal circulating interleukin level 326
                  abnormal circulating interleukin-6 level 198
                    decreased circulating interleukin-6 level 73
paths to the root