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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased circulating tumor necrosis factor level
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Accession:MP:0008553 term browser browse the term
Definition:greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Synonyms:exact_synonym: increased circulating TNFA level;   increased circulating cachectin level;   increased circulating tumor necrosis factor alpha level;   increased circulating tumour necrosis factor alpha level;   increased circulating tumour necrosis factor level
 narrow_synonym: Abnormality of serum cytokine level
 related_synonym: increased circulating TNF level
 xref: HP:0011112


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increased circulating tumor necrosis factor level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arsb arylsulfatase B IAGP RGD PMID:21887218 RGD:39131283 NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671 		JBrowse link
G Gja8 gap junction protein, alpha 8 IAGP RGD PMID:27871290 RGD:150429989 NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456 		JBrowse link
G Gja8m1Cub gap junction protein, alpha 8; mutant 1 Cub IAGP RGD PMID:27871290 RGD:150429989
G Gla galactosidase, alpha IMP compared to wild type RGD PMID:34320241 RGD:401976418 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664 		JBrowse link
G Glaem2Mcwi galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin IMP compared to wild type RGD PMID:34320241 RGD:401976418
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    homeostasis/metabolism phenotype 1423
      abnormal homeostasis 1324
        abnormal protein level 137
          abnormal circulating protein level 109
            increased circulating protein level 65
              increased circulating cytokine level 15
                increased circulating tumor necrosis factor level 8
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    homeostasis/metabolism phenotype 1423
      abnormal homeostasis 1324
        abnormal protein level 137
          abnormal intercellular signaling peptide or protein level 43
            abnormal cytokine level 39
              abnormal circulating cytokine level 29
                abnormal circulating tumor necrosis factor level 12
                  increased circulating tumor necrosis factor level 8
paths to the root