abnormal circulating interferon level - Ontology Report

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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:	abnormal circulating interferon level	go back to main search page
Accession:	MP:0008548	browse the term
Definition:	anomaly in the amount in the blood of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions
Synonyms:	exact_synonym:	abnormal circulating IFN level

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Rat (4) Mouse (155) Human (0) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (2) Strains (2)

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cfb

complement factor B

compared to wild type SHR

RGD

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

complement factor B, ZFN induced mutant 1, Tja

compared to wild type SHR

RGD

Term paths to the root

Path 1
Term	Annotations
mammalian phenotype	5419
immune system phenotype	502
abnormal immune system physiology	384
abnormal immune serum protein physiology	92
abnormal cytokine level	39
abnormal interferon level	7
abnormal circulating interferon level	4
abnormal circulating interferon-alpha level +	0
abnormal circulating interferon-beta level +	0
abnormal circulating interferon-gamma level +	4
Path 2
Term	Annotations
mammalian phenotype	5419
homeostasis/metabolism phenotype	1423
abnormal homeostasis	1324
abnormal protein level	137
abnormal intercellular signaling peptide or protein level	43
abnormal cytokine level	39
abnormal circulating cytokine level	29
abnormal circulating interferon level	4
abnormal circulating interferon-alpha level +	0
abnormal circulating interferon-beta level +	0
abnormal circulating interferon-gamma level +	4

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