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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal gonadotroph morphology
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Accession:MP:0008325 term browser browse the term
Definition:any structural anomaly of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)
Synonyms:exact_synonym: abnormal LH-secreting cells;   abnormal gonadotrope morphology;   abnormal gonadotrophic hormone secreting cell morphology
 narrow_synonym: abnormal FSH cells;   abnormal FSH-producing cells;   abnormal FSH-secreting cells;   abnormal LH cells;   abnormal LH-producing cells


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abnormal gonadotroph morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 IAGP MGI PMID:17026533 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Kl klotho IAGP MGI PMID:9363890 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
G Otx2 orthodenticle homeobox 2 IAGP MGI PMID:23811236 NCBI chr14:48,894,238...48,905,101
Ensembl chr14:48,895,134...48,911,276 		JBrowse link
G Prl prolactin IAGP MGI PMID:12399440 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
absent gonadotrophs term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lhx4 LIM homeobox protein 4 IAGP MGI PMID:12183375 NCBI chr 1:155,573,777...155,627,481
Ensembl chr 1:155,573,777...155,627,430 		JBrowse link
G Pitx2 paired-like homeodomain transcription factor 2 IAGP MGI PMID:11807026 NCBI chr 3:128,993,527...129,013,243
Ensembl chr 3:128,993,527...129,013,240 		JBrowse link
G Prop1 paired like homeodomain factor 1 IAGP MGI PMID:12183375 NCBI chr11:50,841,633...50,844,584
Ensembl chr11:50,841,633...50,844,592 		JBrowse link
decreased gonadotroph cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin (cadherin associated protein), beta 1 IAGP MGI PMID:16678101 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Drd2 dopamine receptor D2 IAGP MGI PMID:9247267 NCBI chr 9:49,251,633...49,319,477
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) IAGP MGI PMID:19439729 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:24100213 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Irs2 insulin receptor substrate 2 IAGP MGI PMID:11014193 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458 		JBrowse link
G Lhx3 LIM homeobox protein 3 IAGP MGI PMID:8638120 PMID:21149718 NCBI chr 2:26,090,224...26,098,261
Ensembl chr 2:26,090,224...26,098,301 		JBrowse link
G Lhx4 LIM homeobox protein 4 IAGP MGI PMID:12183375 NCBI chr 1:155,573,777...155,627,481
Ensembl chr 1:155,573,777...155,627,430 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 IAGP MGI PMID:8563022 NCBI chr 2:38,582,668...38,604,554
Ensembl chr 2:38,582,668...38,604,554 		JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor IAGP MGI PMID:25731822 NCBI chr 2:24,944,370...24,952,893
Ensembl chr 2:24,944,367...24,952,893 		JBrowse link
G Otx2 orthodenticle homeobox 2 IAGP MGI PMID:23811236 NCBI chr14:48,894,238...48,905,101
Ensembl chr14:48,895,134...48,911,276 		JBrowse link
G Pitx1 paired-like homeodomain transcription factor 1 IAGP MGI PMID:10049363 NCBI chr13:55,972,857...55,984,002
Ensembl chr13:55,972,864...55,984,005 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3, neutral IAGP MGI PMID:15764706 NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620 		JBrowse link
G Wnt4 wingless-type MMTV integration site family, member 4 IAGP MGI PMID:9620855 NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037 		JBrowse link
increased gonadotroph cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 (alpha) IAGP MGI PMID:19423761 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Fshr follicle stimulating hormone receptor IAGP MGI PMID:9811848 NCBI chr17:89,292,380...89,508,103
Ensembl chr17:89,292,380...89,508,103 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 15965
    endocrine/exocrine gland phenotype 3151
      abnormal gland morphology 2927
        abnormal endocrine gland morphology 1228
          abnormal neuroendocrine gland morphology 177
            abnormal pituitary gland morphology 149
              abnormal adenohypophysis morphology 104
                abnormal gonadotroph morphology 19
                  decreased gonadotroph cell number + 15
                  decreased gonadotroph cell size 0
                  increased gonadotroph cell number 2
                  increased gonadotroph cell size 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 15965
    nervous system phenotype 4369
      abnormal nervous system morphology 3471
        abnormal brain morphology 2149
          abnormal forebrain morphology 1296
            abnormal diencephalon morphology 349
              abnormal pituitary gland morphology 149
                abnormal adenohypophysis morphology 104
                  abnormal gonadotroph morphology 19
                    decreased gonadotroph cell number + 15
                    decreased gonadotroph cell size 0
                    increased gonadotroph cell number 2
                    increased gonadotroph cell size 0
paths to the root