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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased susceptibility to neuronal excitotoxicity
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Accession:MP:0008235 term browser browse the term
Definition:greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process
Synonyms:exact_synonym: decreased resistance to neuronal excitotoxicity;   increased susceptibility to neurotoxicity-induced cell death


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increased susceptibility to neuronal excitotoxicity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt3 thymoma viral proto-oncogene 3 IAGP MGI PMID:15930105 NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769 		JBrowse link
G Cast calpastatin IAGP MGI PMID:15691848 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929 		JBrowse link
G Cnr1 cannabinoid receptor 1 IAGP MGI PMID:12427832 PMID:14526074 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Dctn1 dynactin 1 IAGP MGI PMID:29490687 NCBI chr 6:83,142,702...83,177,103
Ensembl chr 6:83,142,902...83,177,099 		JBrowse link
G Drd2 dopamine receptor D2 IAGP MGI PMID:11069974 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Gal galanin and GMAP prepropeptide IAGP MGI PMID:15041741 NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit IAGP MGI PMID:17000861 PMID:17804861 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) IAGP MGI PMID:16042312 NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:18327266 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B IAGP MGI PMID:22332140 NCBI chr11:51,490,927...51,497,708
Ensembl chr11:51,490,927...51,497,674 		JBrowse link
G Hpca hippocalcin IAGP MGI PMID:15607944 NCBI chr 4:129,005,363...129,019,712
Ensembl chr 4:129,005,363...129,015,829 		JBrowse link
G Htra2 HtrA serine peptidase 2 IAGP MGI PMID:15509788 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254 		JBrowse link
G Hyou1 hypoxia up-regulated 1 IAGP MGI PMID:11714735 NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666 		JBrowse link
G Il10 interleukin 10 IAGP MGI PMID:10947805 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Lancl1 LanC (bacterial lantibiotic synthetase component C)-like 1 IAGP MGI PMID:25158856 NCBI chr 1:67,039,676...67,078,049
Ensembl chr 1:67,039,676...67,078,031 		JBrowse link
G Lynx1 Ly6/neurotoxin 1 IAGP MGI PMID:16950157 NCBI chr15:74,619,705...74,624,828
Ensembl chr15:74,619,701...74,624,895 		JBrowse link
G Naip1 NLR family, apoptosis inhibitory protein 1 IAGP MGI PMID:10681452 NCBI chr13:100,544,272...100,589,372
Ensembl chr13:100,544,272...100,589,377 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell IAGP MGI PMID:8667023 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Npas4 neuronal PAS domain protein 4 IAGP MGI PMID:19001414 NCBI chr19:5,034,381...5,053,467
Ensembl chr19:5,034,383...5,040,344 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 IAGP MGI PMID:20566846 NCBI chr 2:56,996,845...57,014,018
Ensembl chr 2:56,996,842...57,014,015 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 IAGP MGI PMID:20566846 NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447 		JBrowse link
G Nudt1 nudix hydrolase 1 IAGP MGI PMID:23143307 NCBI chr 5:140,307,377...140,323,892
Ensembl chr 5:140,307,411...140,323,892 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 IAGP MGI PMID:23143307 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide IAGP MGI PMID:16805849 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Psen1 presenilin 1 IAGP MGI PMID:9883847 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IAGP MGI PMID:18355636 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 IAGP MGI PMID:21493629 NCBI chr12:100,514,692...100,691,693
Ensembl chr12:100,514,698...100,693,242 		JBrowse link
G Setx senataxin IAGP MGI PMID:29725819 NCBI chr 2:29,013,600...29,072,483
Ensembl chr 2:29,014,193...29,072,483 		JBrowse link
G Tmem175 transmembrane protein 175 IAGP MGI PMID:33505021 NCBI chr 5:108,777,649...108,795,636
Ensembl chr 5:108,777,636...108,796,648 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a IAGP MGI PMID:8673925 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b IAGP MGI PMID:8673925 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
increased susceptibility to dopaminergic neuron neurotoxicity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IAGP MGI PMID:23500093 NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IAGP MGI PMID:16732273 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IAGP MGI PMID:16732273 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,730,682...119,898,945 		JBrowse link
G Drd2 dopamine receptor D2 IAGP MGI PMID:23242137 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Grn granulin IAGP MGI PMID:23041626 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Il6 interleukin 6 IAGP MGI PMID:12358740 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mir425 microRNA 425 IAGP MGI PMID:31383850 NCBI chr 9:108,445,976...108,446,060
Ensembl chr 9:108,445,976...108,446,060 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 IAGP MGI PMID:24475238 NCBI chr18:38,551,960...38,598,250
Ensembl chr18:38,543,449...38,598,356 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 IAGP MGI PMID:21192928 NCBI chr13:58,954,286...59,281,784
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Otx2 orthodenticle homeobox 2 IAGP MGI PMID:21057506 NCBI chr14:48,894,238...48,905,101
Ensembl chr14:48,895,134...48,911,276 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 IAGP MGI PMID:17560790 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 IAGP MGI PMID:9275230 PMID:11463816 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 IAGP MGI PMID:22143804 NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 IAGP MGI PMID:21057506 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) IAGP MGI PMID:15634780 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16478
    homeostasis/metabolism phenotype 7551
      abnormal physiological response to xenobiotic 768
        increased physiological sensitivity to xenobiotic 343
          increased susceptibility to neuronal excitotoxicity 45
            increased susceptibility to dopaminergic neuron neurotoxicity 15
Path 2
Term Annotations click to browse term
  mammalian phenotype 16478
    cellular phenotype 5267
      abnormal cell physiology 4708
        abnormal cell death 2091
          abnormal apoptosis 1703
            abnormal neuron apoptosis 311
              increased neuron apoptosis 230
                increased susceptibility to neuronal excitotoxicity 45
                  increased susceptibility to dopaminergic neuron neurotoxicity 15
paths to the root