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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased susceptibility to neuronal excitotoxicity
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Accession:MP:0008235 term browser browse the term
Definition:greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process
Synonyms:exact_synonym: decreased resistance to neuronal excitotoxicity;   increased susceptibility to neurotoxicity-induced cell death



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Path 1
Term Annotations click to browse term
  mammalian phenotype 5374
    homeostasis/metabolism phenotype 1396
      abnormal physiological response to xenobiotic 28
        increased physiological sensitivity to xenobiotic 5
          increased susceptibility to neuronal excitotoxicity 0
            increased susceptibility to dopaminergic neuron neurotoxicity 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5374
    cellular phenotype 175
      abnormal cell physiology 139
        abnormal cell death 59
          abnormal apoptosis 43
            abnormal neuron apoptosis 3
              increased neuron apoptosis 0
                increased susceptibility to neuronal excitotoxicity 0
                  increased susceptibility to dopaminergic neuron neurotoxicity 0
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