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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased susceptibility to neuronal excitotoxicity
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Accession:MP:0008235 term browser browse the term
Definition:greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process
Synonyms:exact_synonym: decreased resistance to neuronal excitotoxicity;   increased susceptibility to neurotoxicity-induced cell death



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Path 1
Term Annotations click to browse term
  mammalian phenotype 5415
    homeostasis/metabolism phenotype 1421
      abnormal physiological response to xenobiotic 28
        increased physiological sensitivity to xenobiotic 5
          increased susceptibility to neuronal excitotoxicity 0
            increased susceptibility to dopaminergic neuron neurotoxicity 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5415
    cellular phenotype 187
      abnormal cell physiology 146
        abnormal cell death 53
          abnormal programmed cell death 42
            abnormal apoptosis 42
              abnormal neuron apoptosis 3
                increased neuron apoptosis 0
                  increased susceptibility to neuronal excitotoxicity 0
                    increased susceptibility to dopaminergic neuron neurotoxicity 0
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