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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:absent B-1 B cells
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Accession:MP:0008202 term browser browse the term
Definition:absence of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas


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absent B-1 B cells term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ebf1 early B cell factor 1 IAGP MGI PMID:7542362 NCBI chr11:44,502,738...44,898,923
Ensembl chr11:44,508,144...44,898,918 		JBrowse link
G Igh immunoglobulin heavy chain complex IAGP MGI PMID:14758357 NCBI chr12:113,222,388...115,973,574 JBrowse link
G Igkc immunoglobulin kappa constant IAGP MGI PMID:12538695 NCBI chr 6:70,703,419...70,703,738
Ensembl chr 6:70,703,419...70,703,950 		JBrowse link
G Igl immunoglobulin lambda chain complex IAGP MGI PMID:12538695 NCBI chr16:18,845,608...19,079,594 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IAGP MGI PMID:9586639 NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IAGP MGI PMID:12446777 NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028 		JBrowse link
absent B-1a cells term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blnk B cell linker IAGP MGI PMID:10700474 NCBI chr19:40,917,371...40,982,664
Ensembl chr19:40,917,371...40,982,978 		JBrowse link
G Btk Bruton agammaglobulinemia tyrosine kinase IAGP MGI PMID:8890160 PMID:14634110 NCBI chr  X:133,443,083...133,484,366
Ensembl chr  X:133,443,085...133,484,319 		JBrowse link
G Card11 caspase recruitment domain family, member 11 IAGP MGI PMID:12818158 PMID:12867038 NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337 		JBrowse link
G Cd79a CD79A antigen (immunoglobulin-associated alpha) IAGP MGI PMID:22213803 NCBI chr 7:24,596,922...24,601,283
Ensembl chr 7:24,596,806...24,601,622 		JBrowse link
G Ets1 E26 avian leukemia oncogene 1, 5' domain IAGP MGI PMID:15384043 NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116 		JBrowse link
G Huwe1 HECT, UBA and WWE domain containing 1 IAGP MGI PMID:22213803 NCBI chr  X:150,583,779...150,718,413
Ensembl chr  X:150,583,803...150,718,413 		JBrowse link
G Igh immunoglobulin heavy chain complex IAGP MGI PMID:14758357 NCBI chr12:113,222,388...115,973,574 JBrowse link
G Ikzf1 IKAROS family zinc finger 1 IAGP MGI PMID:8986714 NCBI chr11:11,634,970...11,722,930
Ensembl chr11:11,634,980...11,722,926 		JBrowse link
G Malt1 MALT1 paracaspase IAGP MGI PMID:14576442 NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 IAGP MGI PMID:12833156 NCBI chr19:41,260,980...41,373,541
Ensembl chr19:41,260,816...41,373,541 		JBrowse link
G Trp53 transformation related protein 53 IAGP MGI PMID:22213803 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
absent B-1b cells term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blnk B cell linker IAGP MGI PMID:10583957 NCBI chr19:40,917,371...40,982,664
Ensembl chr19:40,917,371...40,982,978 		JBrowse link
G Igh immunoglobulin heavy chain complex IAGP MGI PMID:14758357 NCBI chr12:113,222,388...115,973,574 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17108
    immune system phenotype 5787
      abnormal immune system morphology 4142
        abnormal immune system cell morphology 2915
          abnormal professional antigen presenting cell morphology 941
            abnormal mature B cell morphology 338
              abnormal B-1 B cell morphology 155
                abnormal B-1 B cell number 154
                  decreased B-1 B cell number 111
                    absent B-1 B cells 16
                      absent B-1a cells 11
                      absent B-1b cells 2
Path 2
Term Annotations click to browse term
  mammalian phenotype 17108
    immune system phenotype 5787
      abnormal immune system morphology 4142
        abnormal immune system cell morphology 2915
          abnormal leukocyte morphology 2896
            abnormal mononuclear cell morphology 2315
              abnormal lymphocyte morphology 1876
                abnormal B cell morphology 800
                  abnormal mature B cell morphology 338
                    abnormal B-1 B cell morphology 155
                      abnormal B-1 B cell number 154
                        decreased B-1 B cell number 111
                          absent B-1 B cells 16
                            absent B-1a cells 11
                            absent B-1b cells 2
paths to the root