abnormal Langerhans cell morphology - Ontology Report

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MAMMALIAN PHENOTYPE - ANNOTATIONS	{{ watchLinkText }}
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:	abnormal Langerhans cell morphology	go back to main search page
Accession:	MP:0008117	browse the term
Definition:	any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus

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Rat (3) Mouse (22) Human (0) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (2) Strains (1)

decreased Langerhans cell number

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Csf1r

colony stimulating factor 1 receptor

IMP

RGD

PMID:30249809

RGD:41404725

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

Csf1r^tm(EGFP)Tset

colony stimulating factor 1 receptor; target mutant, Tset

IMP

RGD

PMID:30249809

RGD:41404725

Term paths to the root

Path 1
Term	Annotations
mammalian phenotype	5380
immune system phenotype	495
abnormal immune system morphology	188
abnormal immune system cell morphology	148
abnormal professional antigen presenting cell morphology	33
abnormal dendritic cell morphology	3
abnormal myeloid dendritic cell morphology	3
abnormal Langerhans cell morphology	3
abnormal Langerhans cell number +	3
Path 2
Term	Annotations
mammalian phenotype	5380
hematopoietic system phenotype	244
abnormal hematopoietic system morphology/development	224
abnormal hematopoietic cell morphology	180
abnormal leukocyte morphology	148
abnormal myeloid leukocyte morphology	64
abnormal phagocyte morphology	41
abnormal mononuclear phagocyte morphology	36
abnormal myeloid dendritic cell morphology	3
abnormal Langerhans cell morphology	3
abnormal Langerhans cell number +	3

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MAMMALIAN PHENOTYPE - ANNOTATIONS