Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased CD8-positive, alpha-beta T cell number
go back to main search page
Accession:MP:0008079 term browser browse the term
Definition:reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
Comment:Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625). Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624). T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
Synonyms:exact_synonym: decreased CD8+ T cell number;   decreased CD8-positive T cell number;   reduced CD8+ T cell number;   reduced CD8-positive T cell number
 related_synonym: Decreased proportion of CD8-positive T cells
 xref: HP:0005415


show annotations for term's descendants           Sort by:
decreased CD8-positive, alpha-beta T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2rg interleukin 2 receptor subunit gamma IMP RGD PMID:29688994 RGD:13628403 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang IMP RGD PMID:29688994 RGD:13628403
G Rag1 recombination activating 1 IMP RGD PMID:29688994 RGD:13628403 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon IMP RGD PMID:29688994 RGD:13628403
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5420
    immune system phenotype 519
      abnormal immune system morphology 211
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal leukocyte cell number 136
              abnormal lymphocyte cell number 93
                abnormal T cell number 63
                  abnormal alpha-beta T cell number 19
                    abnormal CD8-positive, alpha-beta T cell number 9
                      decreased CD8-positive, alpha-beta T cell number 6
                        absent CD8-positive, alpha-beta T cells 0
                        decreased CD8-positive, CD25-positive alpha-beta T cell number 0
                        decreased CD8-positive, alpha-beta memory T cell number + 0
                        decreased KLRG1+ CD8 alpha-beta T cell number 0
                        decreased Tc17 cell number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    immune system phenotype 519
      abnormal immune system morphology 211
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal mononuclear cell morphology 125
              abnormal lymphocyte morphology 97
                abnormal T cell morphology 67
                  abnormal effector T cell morphology 21
                    abnormal CD8-positive, alpha beta T cell morphology 11
                      abnormal CD8-positive, alpha-beta T cell number 9
                        decreased CD8-positive, alpha-beta T cell number 6
                          absent CD8-positive, alpha-beta T cells 0
                          decreased CD8-positive, CD25-positive alpha-beta T cell number 0
                          decreased CD8-positive, alpha-beta memory T cell number + 0
                          decreased KLRG1+ CD8 alpha-beta T cell number 0
                          decreased Tc17 cell number 0
paths to the root