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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased CD8-positive, alpha-beta T cell number
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Accession:MP:0008078 term browser browse the term
Definition:greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
Comment:Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625). Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624). T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
Synonyms:exact_synonym: increased CD8+ T cell number;   increased CD8-positive T cell number



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increased CD8-positive, alpha-beta T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S DA DA IAGP RGD PMID:8909256 RGD:61088
S SHRSP.SHR-(rs197197017 -rs198445122)/Utx IAGP compared to SHR/Utx kidney RGD PMID:32075490 RGD:150429819
S SHRSP/BbbUtx IAGP compared to SHR/Utx, SHRSP.SHR-(rs197197017-rs198445122)/Utx kidney RGD PMID:32075490 RGD:150429819

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5415
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system cell morphology 154
          abnormal leukocyte morphology 154
            abnormal leukocyte cell number 138
              abnormal lymphocyte cell number 93
                abnormal T cell number 63
                  abnormal alpha-beta T cell number 19
                    abnormal CD8-positive, alpha-beta T cell number 9
                      increased CD8-positive, alpha-beta T cell number 3
                        increased CD8-positive, CD25-positive alpha-beta T cell number 0
                        increased CD8-positive, alpha-beta memory T cell number + 0
                        increased KLRG1+ CD8 alpha-beta T cell number 0
                        increased Tc17 cell number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5415
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system cell morphology 154
          abnormal leukocyte morphology 154
            abnormal mononuclear cell morphology 127
              abnormal lymphocyte morphology 99
                abnormal T cell morphology 69
                  abnormal effector T cell morphology 23
                    abnormal CD8-positive, alpha beta T cell morphology 11
                      abnormal CD8-positive, alpha-beta T cell number 9
                        increased CD8-positive, alpha-beta T cell number 3
                          increased CD8-positive, CD25-positive alpha-beta T cell number 0
                          increased CD8-positive, alpha-beta memory T cell number + 0
                          increased KLRG1+ CD8 alpha-beta T cell number 0
                          increased Tc17 cell number 0
paths to the root