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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:decreased CD4-positive, alpha-beta T cell number
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Accession:MP:0008075 term browser browse the term
Definition:reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
Comment:Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625). Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624). T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
Synonyms:exact_synonym: decreased CD4+ T cell number;   decreased CD4-positive T cell number;   reduced CD4+ T cell number



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decreased CD4-positive, alpha-beta T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2rg interleukin 2 receptor subunit gamma IMP RGD PMID:29688994 RGD:13628403 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang IMP RGD PMID:29688994 RGD:13628403
G Rag1 recombination activating 1 IMP RGD PMID:29688994 RGD:13628403 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
JBrowse link
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon IMP RGD PMID:29688994 RGD:13628403

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system cell morphology 154
          abnormal leukocyte morphology 154
            abnormal leukocyte cell number 138
              abnormal lymphocyte cell number 93
                abnormal T cell number 63
                  abnormal alpha-beta T cell number 19
                    abnormal CD4-positive, alpha-beta T cell number 13
                      decreased CD4-positive, alpha-beta T cell number 8
                        absent CD4-positive, alpha-beta T cells 0
                        decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 2
                        decreased CD4-positive, alpha-beta memory T cell number + 0
                        decreased KLRG1+ CD4 alpha-beta T cell number 0
                        decreased T follicular helper cell number 0
                        decreased T helper 1 cell number 0
                        decreased T-helper 17 cell number 0
                        decreased T-helper 2 cell number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system cell morphology 154
          abnormal leukocyte morphology 154
            abnormal mononuclear cell morphology 127
              abnormal lymphocyte morphology 99
                abnormal T cell morphology 69
                  abnormal effector T cell morphology 23
                    abnormal CD4-positive, alpha beta T cell morphology 17
                      abnormal CD4-positive, alpha-beta T cell number 13
                        decreased CD4-positive, alpha-beta T cell number 8
                          absent CD4-positive, alpha-beta T cells 0
                          decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 2
                          decreased CD4-positive, alpha-beta memory T cell number + 0
                          decreased KLRG1+ CD4 alpha-beta T cell number 0
                          decreased T follicular helper cell number 0
                          decreased T helper 1 cell number 0
                          decreased T-helper 17 cell number 0
                          decreased T-helper 2 cell number 0
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