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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased NK cell number
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Accession:MP:0008045 term browser browse the term
Definition:reduction in the number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
Synonyms:exact_synonym: Reduced natural killer cell count;   decreased natural killer cell number;   reduced NK cell number;   reduced natural killer cell number
 xref: CL:0000623;   FMA:63147;   FMA:83601;   HP:0040218


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decreased NK cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il15 interleukin 15 IMP RGD PMID:28395334 RGD:12910490 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il15em1Soar interleukin 15; ZFN induced mutant 1, Soar IMP RGD PMID:28395334 RGD:12910490
G Il2rg interleukin 2 receptor subunit gamma IMP RGD PMID:29688994 RGD:13628403 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang IMP RGD PMID:29688994 RGD:13628403
G Rag1 recombination activating 1 IMP RGD PMID:29688994 RGD:13628403 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon IMP RGD PMID:29688994 RGD:13628403
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    immune system phenotype 498
      abnormal immune system morphology 190
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal leukocyte cell number 136
              abnormal lymphocyte cell number 93
                decreased lymphocyte cell number 72
                  decreased NK cell number 11
                    absent NK cells 0
                    decreased KLRG1-positive NK cell number 0
                    decreased immature NK cell number + 0
                    decreased mature NK cell number + 0
                    decreased memory-marker NK cell number 0
                    decreased uterine NK cell number + 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    immune system phenotype 498
      abnormal immune system morphology 190
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal mononuclear cell morphology 125
              abnormal lymphocyte morphology 97
                abnormal lymphocyte cell number 93
                  decreased lymphocyte cell number 72
                    decreased NK cell number 11
                      absent NK cells 0
                      decreased KLRG1-positive NK cell number 0
                      decreased immature NK cell number + 0
                      decreased mature NK cell number + 0
                      decreased memory-marker NK cell number 0
                      decreased uterine NK cell number + 0
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