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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased NK T cell number
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Accession:MP:0008039 term browser browse the term
Definition:greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments
Synonyms:exact_synonym: increased NK T lymphocyte number;   increased NKT cell number;   increased natural T cell number;   increased natural killer T cell number;   increased natural killer T lymphocyte number



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increased NK T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC, WNT signaling pathway regulator IAGP MGI PMID:22251704 NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605
JBrowse link
G Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 IEA MGI NCBI chr 4:32,238,413...32,586,109
Ensembl chr 4:32,238,804...32,586,108
JBrowse link
G Bahd1 bromo adjacent homology domain containing 1 IEA MGI NCBI chr 2:118,730,817...118,755,009
Ensembl chr 2:118,730,858...118,755,009
JBrowse link
G Card11 caspase recruitment domain family, member 11 IEA MGI NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 IAGP MGI PMID:15593118 NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 IAGP MGI PMID:10843684 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736
JBrowse link
G Chd7 chromodomain helicase DNA binding protein 7 IAGP MGI PMID:36232804 NCBI chr 4:8,690,345...8,868,449
Ensembl chr 4:8,690,406...8,867,659
JBrowse link
G Commd10 COMM domain containing 10 IAGP MGI PMID:33753942 NCBI chr18:47,091,917...47,242,435
Ensembl chr18:47,091,883...47,367,351
JBrowse link
G Ess2 ess-2 splicing factor IAGP MGI PMID:35933014 NCBI chr16:17,718,573...17,729,225
Ensembl chr16:17,718,573...17,729,212
JBrowse link
G Fam3a FAM3 metabolism regulating signaling molecule A IAGP MGI PMID:28562339 NCBI chr  X:73,427,816...73,436,856
Ensembl chr  X:73,428,325...73,436,878
JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase IEA MGI NCBI chr13:32,003,566...32,522,744
Ensembl chr13:32,003,562...32,522,723
JBrowse link
G Ifng interferon gamma IAGP MGI PMID:17475277 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Itgb2 integrin beta 2 IEA MGI NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542
JBrowse link
G Lect2 leukocyte cell-derived chemotaxin 2 IAGP MGI PMID:22251704 NCBI chr13:56,676,772...56,696,373
Ensembl chr13:56,690,277...56,696,315
JBrowse link
G Ltbr lymphotoxin B receptor IEA MGI NCBI chr 6:125,283,534...125,291,026
Ensembl chr 6:125,283,534...125,290,848
JBrowse link
G Nfil3 nuclear factor, interleukin 3, regulated IAGP MGI PMID:19749763 NCBI chr13:53,121,245...53,136,914
Ensembl chr13:53,121,245...53,135,109
JBrowse link
G Plcd1 phospholipase C, delta 1 IAGP MGI PMID:22805570 NCBI chr 9:118,900,595...118,922,570
Ensembl chr 9:118,900,595...118,922,570
JBrowse link
G Psmb11 proteasome (prosome, macropain) subunit, beta type, 11 IEA MGI NCBI chr14:54,862,767...54,867,013
Ensembl chr14:54,858,890...54,867,013
JBrowse link
G Rhoh ras homolog family member H IAGP MGI PMID:17119112 NCBI chr 5:66,018,092...66,054,043
Ensembl chr 5:66,018,556...66,054,043
JBrowse link
G Riok2 RIO kinase 2 IAGP MGI PMID:33753942 NCBI chr17:17,594,594...17,615,161
Ensembl chr17:17,594,571...17,615,161
JBrowse link
G Sesn1 sestrin 1 IAGP MGI PMID:28114291 NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420
JBrowse link
G Sms spermine synthase IAGP MGI PMID:24652767 NCBI chr  X:156,226,847...156,275,283
Ensembl chr  X:156,226,851...156,275,283
JBrowse link
G Socs1 suppressor of cytokine signaling 1 IAGP MGI PMID:11371356 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400
JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate IAGP MGI PMID:24652767 NCBI chr11:72,342,464...72,380,797
Ensembl chr11:72,342,464...72,380,730
JBrowse link
G Spred1 sprouty protein with EVH-1 domain 1, related sequence IEA MGI NCBI chr 2:116,951,576...117,012,760
Ensembl chr 2:116,951,855...117,012,760
JBrowse link
G Stat1 signal transducer and activator of transcription 1 IAGP MGI PMID:17475277 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stk26 serine/threonine kinase 26 IEA MGI NCBI chr  X:49,930,052...49,981,980
Ensembl chr  X:49,929,924...49,981,974
JBrowse link
G Tbk1 TANK-binding kinase 1 IAGP MGI PMID:20651301 NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692
JBrowse link
G Tcra T cell receptor alpha chain IAGP MGI PMID:17785826 PMID:23853545 NCBI chr14:52,665,424...54,461,655 JBrowse link
G Themis thymocyte selection associated IEA MGI NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814
JBrowse link
G Tle4 transducin-like enhancer of split 4 IAGP MGI PMID:25153823 NCBI chr19:14,425,434...14,575,542
Ensembl chr19:14,425,514...14,575,415
JBrowse link
increased CD4-negative NK T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bahd1 bromo adjacent homology domain containing 1 IEA MGI NCBI chr 2:118,730,817...118,755,009
Ensembl chr 2:118,730,858...118,755,009
JBrowse link
G Cog6 component of oligomeric golgi complex 6 IEA MGI NCBI chr 3:52,889,544...52,924,644
Ensembl chr 3:52,889,296...52,924,658
JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase IEA MGI NCBI chr13:32,003,566...32,522,744
Ensembl chr13:32,003,562...32,522,723
JBrowse link
G Sik3 SIK family kinase 3 IEA MGI NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492
JBrowse link
increased CD4-negative, CD25-positive NK T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 IEA MGI NCBI chr10:115,286,219...115,423,685
Ensembl chr10:115,286,216...115,423,685
JBrowse link
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 IEA MGI NCBI chr14:51,164,672...51,168,306
Ensembl chr14:51,163,525...51,168,313
JBrowse link
increased CD4-positive NK T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pax5 paired box 5 IEA MGI NCBI chr 4:44,524,748...44,710,694
Ensembl chr 4:44,524,757...44,710,487
JBrowse link
G Psmb11 proteasome (prosome, macropain) subunit, beta type, 11 IEA MGI NCBI chr14:54,862,767...54,867,013
Ensembl chr14:54,858,890...54,867,013
JBrowse link
G Spred1 sprouty protein with EVH-1 domain 1, related sequence IEA MGI NCBI chr 2:116,951,576...117,012,760
Ensembl chr 2:116,951,855...117,012,760
JBrowse link
G Tppp3 tubulin polymerization-promoting protein family member 3 IEA MGI NCBI chr 8:106,194,124...106,198,189
Ensembl chr 8:106,194,125...106,198,158
JBrowse link
increased CD4-positive, CD25-positive NK T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ubd ubiquitin D IEA MGI NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986
JBrowse link
increased KLRG1-positive CD4-negative NK T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 IEA MGI NCBI chr 4:32,238,413...32,586,109
Ensembl chr 4:32,238,804...32,586,108
JBrowse link
G Sik3 SIK family kinase 3 IEA MGI NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492
JBrowse link
increased Ly6C-positive NK T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef1 Rho guanine nucleotide exchange factor 1 IEA MGI NCBI chr 7:24,601,762...24,626,019
Ensembl chr 7:24,602,337...24,626,019
JBrowse link
G Asb2 ankyrin repeat and SOCS box-containing 2 IEA MGI NCBI chr12:103,287,401...103,322,260
Ensembl chr12:103,287,401...103,322,260
JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase IEA MGI NCBI chr13:32,003,566...32,522,744
Ensembl chr13:32,003,562...32,522,723
JBrowse link
G Nub1 negative regulator of ubiquitin-like proteins 1 IEA MGI NCBI chr 5:24,890,813...24,915,376
Ensembl chr 5:24,890,530...24,915,376
JBrowse link
G Rhobtb1 Rho-related BTB domain containing 1 IEA MGI NCBI chr10:68,987,106...69,127,621
Ensembl chr10:68,987,264...69,127,621
JBrowse link
G Sik3 SIK family kinase 3 IEA MGI NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492
JBrowse link
increased memory-marker CD4-negative NK T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc1b actin related protein 2/3 complex, subunit 1B IEA MGI NCBI chr 5:145,051,066...145,064,996
Ensembl chr 5:145,051,025...145,067,515
JBrowse link
G Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 IEA MGI NCBI chr 4:32,238,413...32,586,109
Ensembl chr 4:32,238,804...32,586,108
JBrowse link
G Bahd1 bromo adjacent homology domain containing 1 IEA MGI NCBI chr 2:118,730,817...118,755,009
Ensembl chr 2:118,730,858...118,755,009
JBrowse link
G Dph6 diphthamine biosynthesis 6 IEA MGI NCBI chr 2:114,346,897...114,485,518
Ensembl chr 2:114,346,897...114,485,445
JBrowse link
G Gimap6 GTPase, IMAP family member 6 IEA MGI NCBI chr 6:48,678,517...48,685,178
Ensembl chr 6:48,678,516...48,685,159
JBrowse link
G Pepd peptidase D IEA MGI NCBI chr 7:34,611,832...34,744,131
Ensembl chr 7:34,611,804...34,744,133
JBrowse link
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit IEA MGI NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567
JBrowse link
increased memory-marker CD4-positive NK T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr2 C-X-C motif chemokine receptor 2 IEA MGI NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
JBrowse link
G Pax5 paired box 5 IEA MGI NCBI chr 4:44,524,748...44,710,694
Ensembl chr 4:44,524,757...44,710,487
JBrowse link
G Psmb11 proteasome (prosome, macropain) subunit, beta type, 11 IEA MGI NCBI chr14:54,862,767...54,867,013
Ensembl chr14:54,858,890...54,867,013
JBrowse link
G Spred1 sprouty protein with EVH-1 domain 1, related sequence IEA MGI NCBI chr 2:116,951,576...117,012,760
Ensembl chr 2:116,951,855...117,012,760
JBrowse link
G Tppp3 tubulin polymerization-promoting protein family member 3 IEA MGI NCBI chr 8:106,194,124...106,198,189
Ensembl chr 8:106,194,125...106,198,158
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16734
    hematopoietic system phenotype 5459
      abnormal hematopoietic system morphology/development 4999
        abnormal hematopoietic cell morphology 4182
          abnormal leukocyte morphology 2783
            abnormal leukocyte cell number 2499
              abnormal lymphocyte cell number 1676
                abnormal T cell number 1056
                  increased T cell number 633
                    increased NK T cell number 52
                      increased CD4-negative NK T cell number + 12
                      increased CD4-positive NK T cell number + 6
                      increased Ly6C-positive NK T cell number 6
Path 2
Term Annotations click to browse term
  mammalian phenotype 16734
    immune system phenotype 5613
      abnormal immune system morphology 4014
        abnormal immune system cell morphology 2804
          abnormal leukocyte morphology 2783
            abnormal mononuclear cell morphology 2239
              abnormal lymphocyte morphology 1813
                abnormal T cell morphology 1151
                  abnormal alpha-beta T cell morphology 870
                    abnormal NK T cell morphology 128
                      abnormal NK T cell number 128
                        increased NK T cell number 52
                          increased CD4-negative NK T cell number + 12
                          increased CD4-positive NK T cell number + 6
                          increased Ly6C-positive NK T cell number 6
paths to the root