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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased apoptosis
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Accession:MP:0006042 term browser browse the term
Definition:greater than normal programmed cell death


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increased apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc39 coiled-coil domain containing 39 IMP RGD PMID:31771992 RGD:150521527 NCBI chr 2:116,665,261...116,703,364
Ensembl chr 2:116,665,261...116,703,350 		JBrowse link
G Ccdc39em1Jgn coiled-coil domain containing 39; CRISPR/Cas9 induced mutant 1, Jgn IMP RGD PMID:31771992 RGD:150521527
G Psen1 presenilin 1 IDA RGD PMID:11895366 RGD:1304239 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Tbc1d1 TBC1 domain family member 1 IMP RGD PMID:28177704 RGD:150521607 NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499 		JBrowse link
G Tbc1d1Tn(sb)1Fkh TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh IMP RGD PMID:28177704 RGD:150521607
increased cardiomyocyte apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm6a lysine demethylase 6A IMP mRNA:incr expr:myocardium (rat) RGD PMID:30887465 RGD:151665136 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Ubd ubiquitin D IMP associated with induced myocardial infarction RGD PMID:29438664 RGD:126925221 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639 		JBrowse link
G Ubdem1 ubiquitin D; CRISPR/Cas9 induced mutant1 IMP associated with induced myocardial infarction RGD PMID:29438664 RGD:126925221
increased kidney apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:35695380 RGD:155630629 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
increased male germ cell apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 IMP RGD PMID:28834365 RGD:14995504 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wwox WW domain-containing oxidoreductase IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391 		JBrowse link
G Wwoxlde WW domain-containing oxidoreductase; lde mutant IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974
increased retina apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde6b phosphodiesterase 6B IMP compared to wild-type RGD PMID:31009522 RGD:40924664 NCBI chr14:1,323,310...1,366,450
Ensembl chr14:1,323,310...1,366,450 		JBrowse link
G Pde6bem1Baek phosphodiesterase 6B; Cpf1-CRISPR induced mutant1, Baek IMP compared to wild-type RGD PMID:31009522 RGD:40924664
increased T cell apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 IMP compared to SD RGD PMID:30262871 RGD:45073131 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon1em1Lizh paraoxonase 1; CRISPR/Cas9 induced mutant 1, Lizh IMP compared to SD RGD PMID:30262871 RGD:45073131
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5373
    cellular phenotype 175
      abnormal cell physiology 139
        abnormal cell death 59
          increased cell death 26
            increased apoptosis 26
              increased B cell apoptosis 0
              increased T cell apoptosis + 4
              increased activation-induced B cell apoptosis 0
              increased activation-induced cell death of T cells 0
              increased adrenal gland apoptosis 0
              increased allantois apoptosis 0
              increased amnion apoptosis 0
              increased anoikis 0
              increased brain apoptosis + 0
              increased cardiomyocyte apoptosis 4
              increased cholangiocyte apoptosis 0
              increased chondrocyte apoptosis 0
              increased embryonic tissue cell apoptosis + 0
              increased enterocyte apoptosis 0
              increased female germ cell apoptosis 0
              increased fetal cardiomyocyte apoptosis 0
              increased fibroblast apoptosis 0
              increased hair follicle apoptosis 0
              increased hepatoblast apoptosis 0
              increased hepatocyte apoptosis 0
              increased keratinocyte apoptosis 0
              increased kidney apoptosis + 1
              increased lacrimal gland apoptosis 0
              increased lens epithelium apoptosis 0
              increased lens fiber apoptosis 0
              increased lung apoptosis + 0
              increased macrophage apoptosis 0
              increased male germ cell apoptosis 4
              increased melanoblast apoptosis 0
              increased myoblast apoptosis 0
              increased neural tube apoptosis + 0
              increased neuron apoptosis + 0
              increased osteoblast apoptosis + 0
              increased otic epithelial cell apoptosis 0
              increased ovary apoptosis + 0
              increased pancreas apoptosis 0
              increased pancreatic beta cell apoptosis 1
              increased placenta apoptosis 0
              increased retina apoptosis 3
              increased skeletal muscle cell apoptosis 0
              increased small intestinal crypt cell apoptosis 0
              increased spinal cord apoptosis 0
              increased splenocyte apoptosis 1
              increased submandibular gland apoptosis 0
              increased testis apoptosis 0
              increased trophectoderm apoptosis 0
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