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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased apoptosis
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Accession:MP:0006042 term browser browse the term
Definition:greater than normal programmed cell death



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increased apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc39 coiled-coil domain 39 molecular ruler complex subunit IMP RGD PMID:31771992 RGD:150521527 NCBI chr 2:116,665,651...116,703,354
Ensembl chr 2:116,665,261...116,703,350
JBrowse link
G Ccdc39em1Jgn coiled-coil domain containing 39; CRISPR/Cas9 induced mutant 1, Jgn IMP RGD PMID:31771992 RGD:150521527
G Psen1 presenilin 1 IDA RGD PMID:11895366 RGD:1304239 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Tbc1d1 TBC1 domain family member 1 IMP RGD PMID:28177704 RGD:150521607 NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
JBrowse link
G Tbc1d1Tn(sb)1Fkh TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh IMP RGD PMID:28177704 RGD:150521607
increased cardiomyocyte apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ubd ubiquitin D IMP associated with induced myocardial infarction RGD PMID:29438664 RGD:126925221 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639
JBrowse link
G Ubdem1 ubiquitin D; CRISPR/Cas9 induced mutant1 IMP associated with induced myocardial infarction RGD PMID:29438664 RGD:126925221
increased kidney apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:35695380 RGD:155630629 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
JBrowse link
increased male germ cell apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 IMP RGD PMID:28834365 RGD:14995504 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Wwox WW domain-containing oxidoreductase IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
JBrowse link
G Wwoxlde WW domain-containing oxidoreductase; lde mutant IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974
increased retina apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde6b phosphodiesterase 6B IMP compared to wild-type RGD PMID:31009522 RGD:40924664 NCBI chr14:1,323,310...1,366,450
Ensembl chr14:1,323,310...1,366,450
JBrowse link
G Pde6bem1Baek phosphodiesterase 6B; Cpf1-CRISPR induced mutant1, Baek IMP compared to wild-type RGD PMID:31009522 RGD:40924664
increased T cell apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 IMP compared to SD RGD PMID:30262871 RGD:45073131 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon1em1Lizh paraoxonase 1; CRISPR/Cas9 induced mutant 1, Lizh IMP compared to SD RGD PMID:30262871 RGD:45073131

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5408
    cellular phenotype 187
      abnormal cell physiology 146
        abnormal cell death 53
          increased cell death 25
            increased apoptosis 25
              increased B cell apoptosis 0
              increased T cell apoptosis + 4
              increased activation-induced B cell apoptosis 0
              increased activation-induced cell death of T cells 0
              increased adipose tissue apoptosis + 0
              increased adrenal gland apoptosis 0
              increased allantois apoptosis 0
              increased amnion apoptosis 0
              increased anoikis 0
              increased brain apoptosis + 0
              increased cardiomyocyte apoptosis 3
              increased cholangiocyte apoptosis 0
              increased chondrocyte apoptosis 0
              increased embryonic tissue cell apoptosis + 0
              increased enterocyte apoptosis 0
              increased female germ cell apoptosis 0
              increased fetal cardiomyocyte apoptosis 0
              increased fibroblast apoptosis 0
              increased hair follicle apoptosis 0
              increased hepatoblast apoptosis 0
              increased hepatocyte apoptosis 0
              increased keratinocyte apoptosis 0
              increased kidney apoptosis + 1
              increased lacrimal gland apoptosis 0
              increased lens epithelium apoptosis 0
              increased lens fiber apoptosis 0
              increased lung apoptosis + 0
              increased macrophage apoptosis 0
              increased male germ cell apoptosis 4
              increased melanoblast apoptosis 0
              increased myoblast apoptosis 0
              increased neural tube apoptosis + 0
              increased neuron apoptosis + 0
              increased osteoblast apoptosis + 0
              increased otic epithelial cell apoptosis 0
              increased ovary apoptosis + 0
              increased pancreas apoptosis 0
              increased pancreatic beta cell apoptosis 1
              increased placenta apoptosis 0
              increased retina apoptosis 3
              increased skeletal muscle cell apoptosis 0
              increased small intestinal crypt cell apoptosis 0
              increased spinal cord apoptosis 0
              increased splenocyte apoptosis 1
              increased submandibular gland apoptosis 0
              increased testis apoptosis 0
              increased trophectoderm apoptosis 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5408
    cellular phenotype 187
      abnormal cell physiology 146
        abnormal cell death 53
          abnormal programmed cell death 42
            abnormal apoptosis 42
              increased apoptosis 25
                increased B cell apoptosis 0
                increased T cell apoptosis + 4
                increased activation-induced B cell apoptosis 0
                increased activation-induced cell death of T cells 0
                increased adipose tissue apoptosis + 0
                increased adrenal gland apoptosis 0
                increased allantois apoptosis 0
                increased amnion apoptosis 0
                increased anoikis 0
                increased brain apoptosis + 0
                increased cardiomyocyte apoptosis 3
                increased cholangiocyte apoptosis 0
                increased chondrocyte apoptosis 0
                increased embryonic tissue cell apoptosis + 0
                increased enterocyte apoptosis 0
                increased female germ cell apoptosis 0
                increased fetal cardiomyocyte apoptosis 0
                increased fibroblast apoptosis 0
                increased hair follicle apoptosis 0
                increased hepatoblast apoptosis 0
                increased hepatocyte apoptosis 0
                increased keratinocyte apoptosis 0
                increased kidney apoptosis + 1
                increased lacrimal gland apoptosis 0
                increased lens epithelium apoptosis 0
                increased lens fiber apoptosis 0
                increased lung apoptosis + 0
                increased macrophage apoptosis 0
                increased male germ cell apoptosis 4
                increased melanoblast apoptosis 0
                increased myoblast apoptosis 0
                increased neural tube apoptosis + 0
                increased neuron apoptosis + 0
                increased osteoblast apoptosis + 0
                increased otic epithelial cell apoptosis 0
                increased ovary apoptosis + 0
                increased pancreas apoptosis 0
                increased pancreatic beta cell apoptosis 1
                increased placenta apoptosis 0
                increased retina apoptosis 3
                increased skeletal muscle cell apoptosis 0
                increased small intestinal crypt cell apoptosis 0
                increased spinal cord apoptosis 0
                increased splenocyte apoptosis 1
                increased submandibular gland apoptosis 0
                increased testis apoptosis 0
                increased trophectoderm apoptosis 0
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