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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased susceptibility to type III hypersensitivity reaction
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Accession:MP:0005615 term browser browse the term
Definition:greater likelihood of developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via antibodies encountering circulating antigen; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury
Comment:Examples of this include: Autoimmune diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren syndrome, scleroderma, and glomerulonephritis.
Synonyms:exact_synonym: decreased resistance to immune complex mediated hypersensitivity;   decreased resistance to type III hypersensitivity reaction;   increased susceptibility to immune complex mediated hypersensitivity



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increased susceptibility to type III hypersensitivity reaction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59em1Ask CD59 molecule; CRISPR/Cas9 induced mutant1, Ask IMP RGD PMID:28212662 RGD:13792592
G Cd59b CD59b molecule IMP RGD PMID:28212662 RGD:13792592 NCBI chr 3:110,914,008...110,932,489 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5421
    immune system phenotype 519
      abnormal immune system physiology 384
        abnormal adaptive immunity 60
          abnormal type III hypersensitivity reaction 3
            increased susceptibility to type III hypersensitivity reaction 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 5421
    immune system phenotype 519
      abnormal immune system physiology 384
        abnormal inflammatory response 229
          abnormal acute inflammation 5
            abnormal type III hypersensitivity reaction 3
              increased susceptibility to type III hypersensitivity reaction 3
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