The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:
increased susceptibility to type III hypersensitivity reaction
greater likelihood of developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via antibodies encountering circulating antigen; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury
Comment:
Examples of this include: Autoimmune diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren syndrome, scleroderma, and glomerulonephritis.
Synonyms:
exact_synonym:
decreased resistance to immune complex mediated hypersensitivity; decreased resistance to type III hypersensitivity reaction; increased susceptibility to immune complex mediated hypersensitivity