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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased susceptibility to type III hypersensitivity reaction
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Accession:MP:0005615 term browser browse the term
Definition:greater likelihood of developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via antibodies encountering circulating antigen; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury
Comment:Examples of this include: Autoimmune diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren syndrome, scleroderma, and glomerulonephritis.
Synonyms:exact_synonym: decreased resistance to immune complex mediated hypersensitivity;   decreased resistance to type III hypersensitivity reaction;   increased susceptibility to immune complex mediated hypersensitivity



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increased susceptibility to type III hypersensitivity reaction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qtnf6 C1q and tumor necrosis factor related protein 6 IAGP MGI PMID:26404464 NCBI chr15:78,407,546...78,416,370
Ensembl chr15:78,407,546...78,415,616
JBrowse link
G Cfh complement component factor h IAGP MGI PMID:12091909 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502
JBrowse link
G Fas Fas cell surface death receptor IAGP MGI PMID:8793508 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16725
    immune system phenotype 5608
      abnormal immune system physiology 3419
        abnormal adaptive immunity 1831
          abnormal type III hypersensitivity reaction 12
            increased susceptibility to type III hypersensitivity reaction 8
Path 2
Term Annotations click to browse term
  mammalian phenotype 16725
    immune system phenotype 5608
      abnormal immune system physiology 3419
        abnormal inflammatory response 1770
          abnormal acute inflammation 411
            abnormal type III hypersensitivity reaction 12
              increased susceptibility to type III hypersensitivity reaction 8
paths to the root