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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal enzyme/coenzyme activity
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Accession:MP:0005584 term browser browse the term
Definition:altered ability of any enzyme or their cofactors, to act as catalysts to induce chemical changes in other substances



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decreased angiotensin I-converting enzyme activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IAGP DNA:repeat:intron:IVS13+40(CA)?-26 RGD PMID:9484988 RGD:8157602 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
decreased brain tyrosine 3-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase IMP RGD PMID:24969022 RGD:13210569 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Park7em1Sage parkinson protein 7; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24969022 RGD:13210569
G Pink1 PTEN induced kinase 1 IMP RGD PMID:24969022 RGD:13210569 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pink1em1Sage PTEN induced putative kinase 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24969022 RGD:13210569
decreased glutathione peroxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja8 gap junction protein, alpha 8 IAGP RGD PMID:27871290 RGD:150429989 NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456
JBrowse link
G Gja8m1Cub gap junction protein, alpha 8; mutant 1 Cub IAGP RGD PMID:27871290 RGD:150429989
decreased NAD(P)H oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyba cytochrome b-245 alpha chain IAGP DNA:deletion:splice junction: RGD PMID:19406829 RGD:11040542 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybam1Sdi cytochrome b-245 alpha chain;mutant 1,Sdi IAGP DNA:deletion:splice junction: RGD PMID:19406829 RGD:11040542
G Ncf2 neutrophil cytosolic factor 2 induces IMP compared to wild-type littermates RGD PMID:22326221 PMID:22326221 RGD:9587793, RGD:9587793 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Ncf2em1Mcwi neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi induces IMP compared to wild-type littermates RGD PMID:22326221 PMID:22326221 RGD:9587793, RGD:9587793
increased angiotensin I-converting enzyme activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IAGP DNA:insertion:intron:IVS16ins287 RGD PMID:16229862 RGD:8157605 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link

Term paths to the root
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  mammalian phenotype 5415
    homeostasis/metabolism phenotype 1421
      abnormal metabolism 76
        abnormal enzyme/coenzyme activity 34
          abnormal 5-aminolevulinate synthase activity + 0
          abnormal NAD(P)H oxidase activity + 8
          abnormal alcohol dehydrogenase activity + 0
          abnormal aldehyde dehydrogenase activity + 0
          abnormal aldehyde oxidase activity + 0
          abnormal alkaline phosphatase activity + 1
          abnormal angiotensin I-converting enzyme activity + 5
          abnormal arylsulphatase activity + 0
          abnormal benzo (alpha) pyrene hydroxylase activity + 0
          abnormal beta-glucuronidase activity + 0
          abnormal catechol O-methyltransferase activity + 0
          abnormal choline O-acetyltransferase activity + 0
          abnormal cholinesterase activity + 0
          abnormal coumarin hydroxylase activity + 0
          abnormal creatine kinase activity + 0
          abnormal delta-aminolaevulinate dehydratase activity + 0
          abnormal glucokinase activity + 0
          abnormal glucose-6-phosphate dehydrogenase activity + 0
          abnormal glutamate decarboxylase activity + 0
          abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity + 0
          abnormal hormone-sensitive lipase activity + 0
          abnormal hydroxymethylbilane synthase activity + 1
          abnormal hypoxanthine phosphoribosyltransferase activity + 0
          abnormal maltase activity + 0
          abnormal monoamine oxidase activity + 0
          abnormal nicotinamide N-methyltransferase activity + 0
          abnormal ornithine carbamoyltransferase activity + 0
          abnormal palmitoyl-(protein) hydrolase activity + 0
          abnormal peroxidase activity + 4
          abnormal phenylalanine decarboxylase activity + 0
          abnormal phosphatidylcholine-sterol O-acyltransferase activity + 0
          abnormal phospholipid transfer protein activity + 0
          abnormal procollagen-proline 4-dioxygenase activity + 0
          abnormal proline oxidase activity + 0
          abnormal purine-nucleoside phosphorylase activity + 0
          abnormal pyruvate kinase activity + 0
          abnormal renin activity + 9
          abnormal thiopurine S-methyltransferase activity + 0
          abnormal triglyceride lipase activity + 0
          abnormal tyrosine 3-monooxygenase activity + 6
          abnormal tyrosine aminotransferase activity + 0
          abnormal urokinase activity + 0
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