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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased circulating thyroxine level
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Accession:MP:0005478 term browser browse the term
Definition:reduction in the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism
Synonyms:exact_synonym: decreased circulating level of T4;   decreased circulating level of thyroxin;   decreased circulating level of thyroxine;   reduced circulating thyroxine level


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decreased circulating thyroxine level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 IAGP MGI PMID:22037765 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Ap1g1 adaptor protein complex AP-1, gamma 1 subunit IAGP MGI PMID:27090238 NCBI chr 8:110,505,215...110,590,842
Ensembl chr 8:110,505,186...110,590,836 		JBrowse link
G B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 IAGP MGI PMID:9013935 NCBI chr 4:40,804,602...40,855,711
Ensembl chr 4:40,804,602...40,854,005 		JBrowse link
G Braf Braf transforming gene IAGP MGI PMID:21512141 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Cand2 cullin associated and neddylation dissociated 2 (putative) IEA MGI NCBI chr 6:115,751,518...115,782,516
Ensembl chr 6:115,751,499...115,782,518 		JBrowse link
G Crym crystallin, mu IAGP MGI PMID:17264173 NCBI chr 7:119,785,603...119,801,212
Ensembl chr 7:119,785,603...119,801,334 		JBrowse link
G Ctsk cathepsin K IAGP MGI PMID:12782676 NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673 		JBrowse link
G Ctsl cathepsin L IAGP MGI PMID:12782676 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 IEA MGI NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405 		JBrowse link
G Dio3 deiodinase, iodothyronine type III IAGP MGI PMID:16410833 NCBI chr12:110,245,664...110,247,531
Ensembl chr12:110,245,502...110,247,531 		JBrowse link
G Duox2 dual oxidase 2 IAGP MGI PMID:17440044 NCBI chr 2:122,109,727...122,129,221
Ensembl chr 2:122,109,728...122,128,930 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 IEA MGI NCBI chr 2:122,129,381...122,133,088
Ensembl chr 2:122,129,381...122,133,366 		JBrowse link
G Gcnt4 glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase) IAGP MGI PMID:19349303 NCBI chr13:97,060,852...97,087,422
Ensembl chr13:97,061,197...97,087,414 		JBrowse link
G Gdap2 ganglioside-induced differentiation-associated-protein 2 IEA MGI NCBI chr 3:100,069,843...100,117,909
Ensembl chr 3:100,069,697...100,114,297 		JBrowse link
G Ghr growth hormone receptor IAGP MGI PMID:11395925 NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974 		JBrowse link
G Gna11 guanine nucleotide binding protein, alpha 11 IAGP MGI PMID:17694176 NCBI chr10:81,364,558...81,380,996
Ensembl chr10:81,364,558...81,381,024 		JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide IAGP MGI PMID:17694176 NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:24374551 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Itprid2 ITPR interacting domain containing 2 IAGP MGI PMID:19156225 NCBI chr 2:79,419,207...79,503,310
Ensembl chr 2:79,465,696...79,503,310 		JBrowse link
G Lepr leptin receptor IAGP MGI PMID:22522563 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lhx3 LIM homeobox protein 3 IAGP MGI PMID:21149718 NCBI chr 2:26,090,224...26,098,261
Ensembl chr 2:26,090,224...26,098,301 		JBrowse link
G Med1 mediator complex subunit 1 IAGP MGI PMID:10882104 NCBI chr11:98,042,980...98,084,121
Ensembl chr11:98,042,980...98,084,119 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IEA MGI NCBI chr 1:152,675,904...152,712,741
Ensembl chr 1:152,675,945...152,712,742 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IAGP MGI PMID:19052228 PMID:21239618 NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal IAGP MGI PMID:22522563 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Oat ornithine aminotransferase IEA MGI NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127 		JBrowse link
G Pax8 paired box 8 IAGP MGI PMID:9590297 PMID:14981357 PMID:25127920 NCBI chr 2:24,310,563...24,365,611
Ensembl chr 2:24,310,572...24,365,611 		JBrowse link
G Pdyn prodynorphin IAGP MGI PMID:17456788 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 IAGP MGI PMID:36719796 NCBI chr 2:24,865,235...24,944,084
Ensembl chr 2:24,866,045...24,944,069 		JBrowse link
G Pomc pro-opiomelanocortin-alpha IAGP MGI PMID:15070780 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 IAGP MGI PMID:15520383 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460 		JBrowse link
G Runx2 runt related transcription factor 2 IAGP MGI PMID:20375239 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Sirt1 sirtuin 1 IAGP MGI PMID:18335035 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), member 2 IAGP MGI PMID:16709608 PMID:17318265 NCBI chr  X:102,741,020...102,865,594
Ensembl chr  X:102,741,020...102,865,589 		JBrowse link
G Slc26a7 solute carrier family 26, member 7 IAGP MGI PMID:30333321 NCBI chr 4:14,502,430...14,621,946
Ensembl chr 4:14,502,430...14,621,805 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 IAGP MGI PMID:28461334 NCBI chr 1:185,187,045...185,200,959
Ensembl chr 1:185,187,045...185,200,959 		JBrowse link
G Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 IAGP MGI PMID:28706256 NCBI chr 8:71,335,529...71,345,429
Ensembl chr 8:71,335,533...71,345,401 		JBrowse link
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 IAGP MGI PMID:19052228 NCBI chr13:3,199,475...3,239,678
Ensembl chr13:3,236,206...3,239,317
Ensembl chr13:3,236,206...3,239,317 		JBrowse link
G Tg thyroglobulin IAGP MGI PMID:3803305 NCBI chr15:66,542,606...66,722,570
Ensembl chr15:66,542,602...66,722,570 		JBrowse link
G Thra thyroid hormone receptor alpha IAGP MGI PMID:11159823 PMID:11726557 PMID:11731613 PMID:12576486 PMID:17327419 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Thrb thyroid hormone receptor beta IAGP MGI PMID:8670802 PMID:11726557 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Tpst2 protein-tyrosine sulfotransferase 2 IAGP MGI PMID:7964294 NCBI chr 5:112,424,548...112,463,222
Ensembl chr 5:112,424,557...112,463,227 		JBrowse link
G Trh thyrotropin releasing hormone IAGP MGI PMID:10628753 NCBI chr 6:92,219,042...92,221,631
Ensembl chr 6:92,219,042...92,221,631 		JBrowse link
G Trhr thyrotropin releasing hormone receptor IAGP MGI PMID:17666589 PMID:25490146 NCBI chr15:44,059,314...44,099,308
Ensembl chr15:44,059,531...44,099,308 		JBrowse link
G Tshr thyroid stimulating hormone receptor IAGP MGI PMID:7209519 PMID:12432094 NCBI chr12:91,367,767...91,507,283
Ensembl chr12:91,351,337...91,516,582 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) IAGP MGI PMID:12569166 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Vgf VGF nerve growth factor inducible IAGP MGI PMID:10433265 NCBI chr 5:137,054,156...137,062,205
Ensembl chr 5:137,055,246...137,062,205 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16532
    homeostasis/metabolism phenotype 7569
      abnormal homeostasis 6733
        abnormal blood homeostasis 5185
          abnormal circulating hormone level 1145
            abnormal circulating thyroxine level 65
              decreased circulating thyroxine level 47
Path 2
Term Annotations click to browse term
  mammalian phenotype 16532
    homeostasis/metabolism phenotype 7569
      abnormal homeostasis 6733
        abnormal hormone level 1279
          abnormal thyroid hormone level 85
            abnormal thyroxine level 76
              decreased thyroxine level 55
                decreased circulating thyroxine level 47
paths to the root