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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal neurotransmitter secretion
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Accession:MP:0005445 term browser browse the term
Definition:anomaly in the production or release of endogenous signaling molecules into a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell
Synonyms:exact_synonym: abnormal neurotransmitter release;   abnormal synaptic release


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abnormal neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grm2 glutamate metabotropic receptor 2 IMP knock-out compared to wild-type rats
knockout compared to wild type		 RGD PMID:30283001 PMID:28700935 RGD:38501063, RGD:38501064 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:28700935 PMID:30283001 RGD:38501064, RGD:38501063
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  mammalian phenotype 5417
    nervous system phenotype 376
      abnormal nervous system physiology 218
        abnormal synaptic physiology 47
          abnormal synaptic transmission 46
            abnormal neurotransmitter secretion 5
              abnormal synaptic acetylcholine release 1
              abnormal synaptic dopamine release 1
              abnormal synaptic epinephrine release 0
              abnormal synaptic glutamate release + 1
              abnormal synaptic norepinephrine release 0
              abnormal synaptic vesicle exocytosis 0
              decreased neurotransmitter release + 2
              increased neurotransmitter release 0
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