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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal mesangial cell morphology
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Accession:MP:0005327 term browser browse the term
Definition:any structural anomaly of the modified smooth muscle cells that are interposed between endothelial cells and the basement membrane in the central or stalk region of the capillary tuft of the renal glomerulus, which regulate blood flow by their contractile activity, and secrete extracellular matrix, prostaglandins, and cytokines; mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier
Synonyms:exact_synonym: abnormal deep cell;   abnormal intercapillary cell;   abnormal intraglomerular mesangial cell


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abnormal mesangial cell morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxc2 forkhead box C2 IAGP MGI PMID:16498405 NCBI chr 8:121,842,910...121,845,634
Ensembl chr 8:121,842,910...121,845,634 		JBrowse link
G Lama5 laminin, alpha 5 IAGP MGI PMID:10625553 NCBI chr 2:179,818,166...179,867,652
Ensembl chr 2:179,818,166...179,867,652 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide IAGP MGI PMID:11124809 PMID:11239463 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain IAGP MGI PMID:21948081 NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497 		JBrowse link
G Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 IAGP MGI PMID:16987502 NCBI chr17:57,496,437...57,501,182
Ensembl chr17:57,496,492...57,501,177 		JBrowse link
G Vegfa vascular endothelial growth factor A IAGP MGI PMID:12039984 PMID:12618525 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Wt1 WT1 transcription factor IAGP MGI PMID:10077614 PMID:18040647 PMID:19797313 NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961 		JBrowse link
absent mesangial cell term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch2 notch 2 IAGP MGI PMID:11171333 NCBI chr 3:97,920,854...98,057,683
Ensembl chr 3:97,920,843...98,057,677 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide IAGP MGI PMID:7958863 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide IAGP MGI PMID:7958864 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
decreased mesangial cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgdia Rho GDP dissociation inhibitor alpha IAGP MGI PMID:10498891 NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450 		JBrowse link
G Gpr4 G protein-coupled receptor 4 IAGP MGI PMID:17145776 NCBI chr 7:18,946,463...18,958,101
Ensembl chr 7:18,946,463...18,958,099 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide IAGP MGI PMID:7958863 PMID:12897053 PMID:15084468 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
increased mesangial cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bsg basigin IAGP MGI PMID:25891969 NCBI chr10:79,540,192...79,547,813
Ensembl chr10:79,540,325...79,547,803 		JBrowse link
G Cd151 CD151 antigen IAGP MGI PMID:17015618 NCBI chr 7:141,047,275...141,051,394
Ensembl chr 7:141,047,305...141,051,386 		JBrowse link
G Cd2ap CD2-associated protein IAGP MGI PMID:10514378 PMID:12764198 NCBI chr17:43,059,857...43,187,593
Ensembl chr17:43,103,842...43,187,556 		JBrowse link
G Cd2bp2 CD2 cytoplasmic tail binding protein 2 IAGP MGI PMID:26082520 NCBI chr 7:126,790,832...126,795,249
Ensembl chr 7:126,790,832...126,795,222 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A IAGP MGI PMID:11970874 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta IAGP MGI PMID:7744000 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cfh complement component factor h IAGP MGI PMID:12091909 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502 		JBrowse link
G Cfi complement component factor i IAGP MGI PMID:34149444 NCBI chr 3:129,630,432...129,668,978
Ensembl chr 3:129,629,533...129,668,981 		JBrowse link
G Clec2h C-type lectin domain family 2, member h IAGP MGI PMID:35318366 NCBI chr 6:128,639,348...128,654,337
Ensembl chr 6:128,639,348...128,654,337 		JBrowse link
G Clu clusterin IAGP MGI PMID:11865066 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Cmas cytidine monophospho-N-acetylneuraminic acid synthetase IAGP MGI PMID:31040189 NCBI chr 6:142,702,468...142,721,440
Ensembl chr 6:142,702,412...142,721,440 		JBrowse link
G Col4a3 collagen, type IV, alpha 3 IAGP MGI PMID:8956999 NCBI chr 1:82,564,647...82,699,778
Ensembl chr 1:82,564,642...82,699,780 		JBrowse link
G Col4a5 collagen, type IV, alpha 5 IAGP MGI PMID:15153557 NCBI chr  X:140,258,367...140,472,232
Ensembl chr  X:140,258,381...140,472,230 		JBrowse link
G Fas Fas cell surface death receptor IAGP MGI PMID:6609979 PMID:12097414 PMID:12571859 PMID:17142777 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide IAGP MGI PMID:12571859 NCBI chr 1:171,057,141...171,061,918
Ensembl chr 1:171,057,141...171,061,934 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha IAGP MGI PMID:11970874 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor IAGP MGI PMID:20943767 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:18327259 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 IAGP MGI PMID:20484117 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
G Ifng interferon gamma IAGP MGI PMID:12097414 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igh immunoglobulin heavy chain complex IAGP MGI PMID:16973388 NCBI chr12:113,222,388...115,973,574 JBrowse link
G Igk immunoglobulin kappa chain complex IAGP MGI PMID:16973388 NCBI chr 6:67,532,620...70,703,738 JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) IAGP MGI PMID:18328474 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681 		JBrowse link
G Junb jun B proto-oncogene IAGP MGI PMID:19918056 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347 		JBrowse link
G Kirrel1 kirre like nephrin family adhesion molecule 1 IAGP MGI PMID:11416156 NCBI chr 3:86,985,900...87,082,084
Ensembl chr 3:86,985,900...87,082,054 		JBrowse link
G Lcat lecithin cholesterol acyltransferase IAGP MGI PMID:11278414 PMID:15466392 NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014 		JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:21135166 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Mark2 MAP/microtubule affinity regulating kinase 2 IAGP MGI PMID:11287624 NCBI chr19:7,252,761...7,319,222
Ensembl chr19:7,252,761...7,319,225 		JBrowse link
G Mta2 metastasis-associated gene family, member 2 IAGP MGI PMID:18353770 NCBI chr19:8,919,239...8,929,659
Ensembl chr19:8,919,239...8,929,667 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 IAGP MGI PMID:11576348 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell IAGP MGI PMID:19036847 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nphs1 nephrosis 1, nephrin IAGP MGI PMID:11136707 NCBI chr 7:30,157,259...30,188,048
Ensembl chr 7:30,157,740...30,186,648 		JBrowse link
G Nphs2 nephrosis 2, podocin IAGP MGI PMID:19713307 NCBI chr 1:156,138,105...156,155,605
Ensembl chr 1:156,138,297...156,155,605 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 IAGP MGI PMID:38379085 NCBI chr17:64,588,001...64,638,878
Ensembl chr17:64,588,000...64,638,911 		JBrowse link
G Pkhd1 polycystic kidney and hepatic disease 1 IAGP MGI PMID:18235088 NCBI chr 1:20,128,003...20,688,306
Ensembl chr 1:20,128,003...20,688,288 		JBrowse link
G Pkn1 protein kinase N1 IAGP MGI PMID:23223530 NCBI chr 8:84,393,162...84,425,819
Ensembl chr 8:84,393,165...84,425,808 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma IAGP MGI PMID:21135166 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Rag1 recombination activating 1 IAGP MGI PMID:35318366 NCBI chr 2:101,468,597...101,479,877
Ensembl chr 2:101,468,627...101,479,846 		JBrowse link
G Rxra retinoid X receptor alpha IAGP MGI PMID:21135166 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Selp selectin, platelet IAGP MGI PMID:17142777 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Six2 sine oculis-related homeobox 2 IAGP MGI PMID:33514561 NCBI chr17:85,970,276...85,995,682
Ensembl chr17:85,991,705...85,995,702 		JBrowse link
G Slc12a4 solute carrier family 12, member 4 IAGP MGI PMID:26450986 NCBI chr 8:106,670,222...106,692,781
Ensembl chr 8:106,670,222...106,692,729 		JBrowse link
G Srgap1 SLIT-ROBO Rho GTPase activating protein 1 IAGP MGI PMID:33514561 NCBI chr10:121,616,896...121,883,740
Ensembl chr10:121,616,896...121,883,220 		JBrowse link
G Syk spleen tyrosine kinase IAGP MGI PMID:22728826 NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828 		JBrowse link
G Tcrb T cell receptor beta chain IAGP MGI PMID:22585710 NCBI chr 6:40,868,230...41,535,305 JBrowse link
G Tcrd T-cell receptor delta chain IAGP MGI PMID:22585710 NCBI chr14:54,183,530...54,396,655 JBrowse link
G Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b IAGP MGI PMID:12594954 NCBI chr11:61,017,567...61,040,435
Ensembl chr11:61,017,581...61,040,198 		JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 IAGP MGI PMID:22585710 NCBI chr10:39,488,930...39,531,303
Ensembl chr10:39,488,930...39,531,303 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor IAGP MGI PMID:20522651 NCBI chr 6:113,600,955...113,608,595
Ensembl chr 6:113,600,920...113,608,594 		JBrowse link
G Was Wiskott-Aldrich syndrome IAGP MGI PMID:22079330 NCBI chr  X:7,947,705...7,956,730
Ensembl chr  X:7,947,692...7,956,737 		JBrowse link
G Wt1 WT1 transcription factor IAGP MGI PMID:10077614 PMID:18040647 NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961 		JBrowse link
mesangial cell interposition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin dependent kinase inhibitor 1A IAGP MGI PMID:11970874 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cfh complement component factor h IAGP MGI PMID:12091909 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502 		JBrowse link
G Ehd3 EH-domain containing 3 IAGP MGI PMID:21408024 NCBI chr17:74,111,836...74,139,088
Ensembl chr17:74,111,129...74,139,089 		JBrowse link
G Ehd4 EH-domain containing 4 IAGP MGI PMID:21408024 NCBI chr 2:119,919,958...119,985,028
Ensembl chr 2:119,919,656...119,985,087 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha IAGP MGI PMID:11970874 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IAGP MGI PMID:19150426 NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16963
    cellular phenotype 5412
      abnormal cell morphology 2007
        abnormal mesangial cell morphology 64
          decreased mesangial cell number + 5
          increased mesangial cell number 51
          mesangial cell interposition 6
Path 2
Term Annotations click to browse term
  mammalian phenotype 16963
    renal/urinary system phenotype 2126
      abnormal renal/urinary system morphology 1768
        abnormal kidney morphology 1580
          abnormal kidney cortex morphology 485
            abnormal renal corpuscle morphology 448
              abnormal renal glomerulus morphology 413
                abnormal glomerular mesangium morphology 112
                  abnormal mesangial cell morphology 64
                    decreased mesangial cell number + 5
                    increased mesangial cell number 51
                    mesangial cell interposition 6
paths to the root