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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal Harderian gland morphology
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Accession:MP:0005248 term browser browse the term
Definition:any structural anomaly of the retroocular sebaceous gland found within the orbit of mammals that possess a nictitating membrane (third eyelid); the chief products of the gland vary between different groups of vertebrates, and epithelial cells possess granules or vacuoles whose contents may be mucous, serous or lipid; in rodents, the Harderian gland is especially large and secretes lipids (by a merocrine mechanism), melatonin and porphyrins; ascribed functions include a role in lubrication and protection for the eyeball and nictitating membrane (by lipids), photoprotection (by porphyrin), photoreception (by regulation of the incidence of light on the retina), and thermoregulation (in some rodents) of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane
Comment:The Harderian gland does not normally exist in some types of mammals (bats, cows and horses), terrestrial carnivores, and higher primates including human.
Synonyms:exact_synonym: Harderian gland abnormalities;   Harderian gland dysplasia

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  mammalian phenotype 5402
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal exocrine gland morphology 119
          abnormal merocrine gland morphology 0
            abnormal Harderian gland morphology 0
              abnormal Harderian gland development 0
              abnormal Harderian gland pigmentation 0
              abnormal Harderian gland size + 0
              absent Harderian gland 0
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