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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal pancreatic beta cell morphology
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Accession:MP:0005217 term browser browse the term
Definition:any structural anomaly of a cell that secretes insulin and is located towards the center of the islets of Langerhans in the pancreas
Synonyms:exact_synonym: abnormal insulin-secreting cells;   abnormal pancreatic B cells;   abnormal pancreatic beta cells;   abnormal type B enteroendocrine cell morphology



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decreased pancreatic beta cell mass term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tbc1d1 TBC1 domain family member 1 induces IMP compared to Wild type RGD PMID:28177704 RGD:150521607 NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
JBrowse link
G Tbc1d1Tn(sb)1Fkh TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh induces IMP compared to Wild type RGD PMID:28177704 RGD:150521607
G Wfs1 wolframin ER transmembrane glycoprotein onset IMP RGD PMID:28860598 RGD:149735331 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
JBrowse link
G Wfs1em1Ptsn wolframin ER transmembrane glycoprotein; ZFN induced mutant 1 onset IMP RGD PMID:28860598 RGD:149735331

Term paths to the root
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  mammalian phenotype 5364
    endocrine/exocrine gland phenotype 390
      abnormal gland morphology 330
        abnormal endocrine gland morphology 143
          abnormal endocrine pancreas morphology 24
            abnormal pancreatic islet morphology 24
              abnormal pancreatic beta cell morphology 10
                abnormal pancreatic beta cell differentiation 0
                abnormal pancreatic beta cell mass + 10
                abnormal pancreatic beta cell number + 1
                degranulated pancreatic beta cells 0
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