impaired natural killer cell mediated cytotoxicity - Ontology Report

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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:	impaired natural killer cell mediated cytotoxicity	go back to main search page
Accession:	MP:0005070	browse the term
Definition:	impaired ability of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors
Synonyms:	exact_synonym:	defective NK cell cytolysis; defective natural killer cell cytolysis; impaired NK cell cytolysis; impaired NK cell mediated cell death; impaired NK cell mediated cell killing; impaired NK cell mediated cytolysis; impaired NK cell mediated cytotoxicity; impaired natural killer cell mediated cell death; impaired natural killer cell mediated cell killing; impaired natural killer cell mediated cytolysis
	broad_synonym:	impaired killer activity

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Rat (5) Mouse (69) Human (0) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (2) QTL (1) Strains (2)

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Dpp4

dipeptidylpeptidase 4

compared to DA/Ztm

RGD

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

dipeptidylpeptidase 4; DPPIV mutant

compared to DA/Ztm

RGD

Term paths to the root

Path 1
Term	Annotations
mammalian phenotype	5420
immune system phenotype	502
abnormal immune system physiology	384
abnormal innate immunity	24
abnormal NK cell physiology	5
abnormal natural killer cell mediated cytotoxicity	5
impaired natural killer cell mediated cytotoxicity	5
Path 2
Term	Annotations
mammalian phenotype	5420
immune system phenotype	502
abnormal immune system physiology	384
abnormal adaptive immunity	60
abnormal leukocyte physiology	56
abnormal lymphocyte physiology	49
abnormal NK cell physiology	5
abnormal natural killer cell mediated cytotoxicity	5
impaired natural killer cell mediated cytotoxicity	5

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