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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal eosinophil morphology
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Accession:MP:0005061 term browser browse the term
Definition:any structural anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions
Synonyms:exact_synonym: abnormal eosinocyte morphology;   abnormal eosinophilic leucocyte morphology;   abnormal eosinophilic leukocyte morphology;   eosinophil structural abnormalities
 broad_synonym: abnormal polymorphonuclear leucocyte morphology;   abnormal polymorphonuclear leukocyte morphology


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decreased eosinophil cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp4 dipeptidylpeptidase 4 IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336 NCBI chr 3:46,962,243...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Dpp4DPPIV dipeptidylpeptidase 4; DPPIV mutant IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336
G Fh fumarate hydratase IMP RGD PMID:27556703 RGD:13792708 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fhem1 fumarate hydratase; TALEN induced mutant 1 IMP RGD PMID:27556703 RGD:13792708
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:23799078 RGD:13462048 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:23799078 RGD:13462048
increased eosinophil cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyba cytochrome b-245 alpha chain IAGP compared to BN/SsN RGD PMID:21512270 RGD:5134988 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybam1Sdi cytochrome b-245 alpha chain;mutant 1,Sdi IAGP compared to BN/SsN RGD PMID:21512270 RGD:5134988
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5373
    hematopoietic system phenotype 243
      abnormal hematopoietic system morphology/development 223
        abnormal bone marrow cell morphology/development 28
          abnormal myeloblast morphology/development 21
            abnormal eosinophil morphology 18
              abnormal eosinophil cell number + 18
              abnormal eosinophil differentiation 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5373
    hematopoietic system phenotype 243
      abnormal hematopoietic system morphology/development 223
        abnormal hematopoietic cell morphology 179
          abnormal leukocyte morphology 147
            abnormal myeloid leukocyte morphology 64
              abnormal granulocyte morphology 43
                abnormal eosinophil morphology 18
                  abnormal eosinophil cell number + 18
                  abnormal eosinophil differentiation 0
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