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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal CD8-positive, alpha beta T cell morphology
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Accession:MP:0005010 term browser browse the term
Definition:any structural anomaly of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
Comment:Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625). Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624). T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
Synonyms:exact_synonym: CD8+ T cell abnormalities;   abnormal CD8+ T cell morphology;   abnormal CD8-positive T cell morphology
 broad_synonym: abnormal single positive T cell morphology



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  mammalian phenotype 8
    immune system phenotype 0
      abnormal immune system morphology 0
        abnormal immune system cell morphology 0
          abnormal leukocyte morphology 0
            abnormal mononuclear cell morphology 0
              abnormal lymphocyte morphology 0
                abnormal T cell morphology 0
                  abnormal effector T cell morphology 0
                    abnormal CD8-positive, alpha beta T cell morphology 0
                      abnormal CD8 positive, alpha-beta intraepithelial T cell morphology 0
                      abnormal CD8-positive, alpha-beta T cell differentiation 0
                      abnormal CD8-positive, alpha-beta T cell number + 0
                      abnormal CD8-positive, alpha-beta cytotoxic T cell morphology 0
                      abnormal CD8-positive, alpha-beta memory T cell morphology + 0
                      abnormal CD8-positive, alpha-beta regulatory T cell morphology 0
                      abnormal Tc17 cell morphology + 0
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